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The Effect of Metformin Treatment on Thyroid Hormone Metabolism in Euthyroid Patients With Type 2 Diabetes Mellitus

This study has been completed.
Information provided by:
Haydarpasa Numune State Hospital Identifier:
First received: April 19, 2007
Last updated: NA
Last verified: March 2007
History: No changes posted
Aim: To investigate the effects of metformin treatment on thyroid hormone metabolism in euthyroid patients with type 2 diabetes mellitus.

Condition Intervention Phase
Diabetes Mellitus, Type 2
Drug: Metformin
Phase 4

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Open Label

Resource links provided by NLM:

Further study details as provided by Haydarpasa Numune State Hospital:


Ages Eligible for Study:   35 Years to 78 Years   (Adult, Senior)
Sexes Eligible for Study:   All

Inclusion Criteria:

  • The patients included in this study were the ones who were newly diagnosed with type 2 diabetes mellitus

Exclusion Criteria:

  • Presence of thyroid disorders, positive thyroid autoantibodies and usage of medications affecting thyroid hormones such as amiodarone, lithium were accepted as exclusion criterions
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Please refer to this study by its identifier: NCT00463502

Sponsors and Collaborators
Haydarpasa Numune State Hospital
Principal Investigator: Ali Ozdemir Unaffiliation
  More Information Identifier: NCT00463502     History of Changes
Other Study ID Numbers: 07-013
Study First Received: April 19, 2007
Last Updated: April 19, 2007

Keywords provided by Haydarpasa Numune State Hospital:
The purpose of study was investigated the effect of
metformin on thyroid hormone metabolism in euthyroid patients
with type 2 DM. The results revealed significant decreases
in TSH and fT4

Additional relevant MeSH terms:
Diabetes Mellitus
Diabetes Mellitus, Type 2
Glucose Metabolism Disorders
Metabolic Diseases
Endocrine System Diseases
Hypoglycemic Agents
Physiological Effects of Drugs processed this record on April 26, 2017