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Postoperative Delirium at Heidelberg's Intensive Care Unit -New Diagnostic Markers

This study has been completed.
Sponsor:
Collaborator:
Else Kröner Fresenius Foundation
Information provided by:
Heidelberg University
ClinicalTrials.gov Identifier:
NCT00463333
First received: September 10, 2005
Last updated: April 19, 2007
Last verified: April 2007
  Purpose

Summary:

Postoperative delirium is a highly prevalent disease (10–30% prevalence) after surgery in intensive care unit, however, it is often misdiagnosed and mistreated. The aim of the present project is to investigate risk factors for postoperative delirium in more detail, to evaluate respective cognitive test systems and to measure EEG activity parallel to patients’ serum anticholinergic activity. The pathophysiology of delirium is unknown up to now: a possible dysbalance between cerebral acetylcholine and dopamine concentrations is a likely hypothesis. Therefore, the measurement of peripheral serum anticholinergic activity could be a new prognostic factor for evaluation of delirium. Because delirium is also associated with higher postoperative mortality and morbidity, with delayed functional recovery, and postoperative delirium makes patient management much more difficult, increases costs, and, above all, causes severe discomfort to the patient new interdisciplinary diagnostic strategies are necessary to resolve this problem.


Condition
Postoperative Delirium

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Heidelberg University:

Study Start Date: May 2005
  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • All patients at Intensive Care Unit over a defined time period
  • Over 18 years old

Exclusion Criteria:

  • Elective heart and vascular patients
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00463333

Locations
Germany
Intensive Care Unit, Clinic of Anesthesiology
Heidelberg, Germany, 69120
Sponsors and Collaborators
Heidelberg University
Else Kröner Fresenius Foundation
Investigators
Principal Investigator: Markus A Weigand, PhD, MD Medical Faculty, Clinic of Anesthesiology, University of Heidelberg
Principal Investigator: Konstanze Plaschke, Prof. Clinic of Anesthesiology
  More Information

Publications automatically indexed to this study by ClinicalTrials.gov Identifier (NCT Number):
ClinicalTrials.gov Identifier: NCT00463333     History of Changes
Other Study ID Numbers: 196/2004
Study First Received: September 10, 2005
Last Updated: April 19, 2007

Keywords provided by Heidelberg University:
postoperative delirium
psychometric testing
EEG
serum markers

Additional relevant MeSH terms:
Delirium
Confusion
Neurobehavioral Manifestations
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms
Neurocognitive Disorders
Mental Disorders

ClinicalTrials.gov processed this record on August 18, 2017