Diet and the Aging Brain

The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details. Identifier: NCT00463255
Recruitment Status : Completed
First Posted : April 20, 2007
Last Update Posted : November 8, 2011
Information provided by:
University Hospital Muenster

Brief Summary:
We investigate whether a change in diet could provide positive effects on general brain functions in healthy elderly people.

Condition or disease Intervention/treatment Phase
Healthy Behavioral: diet Phase 3

Detailed Description:

The age-related degradation of cognitive functions even to the point of neurodegenerative disorders such as alzheimer`s disease are a growing public-health concern with potentially devastating effects.

Refering to animal data and empirical studies, a healthy diet rich in unsaturated fatty acids and low in calories should improve cognitive functions such as learning and memory. To test this hypothesis, we study general brain functions in healthy elderly subjects (50-80 years old) during a short term diet.

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 120 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Prevention
Official Title: Phase IV Interventional Study: Effect of Diet on Brain Function in Elderly Healthy People
Study Start Date : August 2006
Actual Study Completion Date : October 2008

Primary Outcome Measures :
  1. implicit visual-motor learning of a finger sequence of the hand.

Secondary Outcome Measures :
  1. implicit learning of an artificial language
  2. several plasma levels related to cognitive functions

Information from the National Library of Medicine

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Ages Eligible for Study:   50 Years to 80 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • healthy subjects
  • 50-80 years old
  • moderate to heavy weight
  • must be able to change diet at home

Exclusion Criteria:

  • diabetes
  • younger than 50 years
  • BMI < 23
  • already participating in other studys
  • MMSE > 26
  • eating disorders

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its identifier (NCT number): NCT00463255

University Hospital Muenster, Department of Neurology
Muenster, NRW, Germany, 48149
Sponsors and Collaborators
University Hospital Muenster
Study Chair: Stefan Knecht, MD, Prof. University Hospital Muenster
Study Chair: Bernd E Ringelstein, MD, Prof University Hopsital Muenster
Principal Investigator: Agnes Floeel, MD University Hospital Muenster Identifier: NCT00463255     History of Changes
Other Study ID Numbers: Ernaehrung-Neuromod 01
First Posted: April 20, 2007    Key Record Dates
Last Update Posted: November 8, 2011
Last Verified: November 2011

Keywords provided by University Hospital Muenster:
age-related diseases
cognitive decline
Clinical study