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Functional MRI of Cognitive Control in Autism

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified April 2007 by UMC Utrecht.
Recruitment status was:  Not yet recruiting
Information provided by:
UMC Utrecht Identifier:
First received: April 19, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted
This study aims to investigate the role of fronto-striatal circuits and cognitive control in the perseverative and inflexible behavior that is a defining feature of autism. We hypothesize that deficits in the development of fronto-striatal circuitry may underlie cognitive inflexibility in autism. Specifically, we hypothesize that repetitive, inflexible behavior arises as (1) fronto-striatal systems are capable of learning patterns present in the environment (as in implicit learning paradigms), but are unable to adapt behavior to changing circumstances, related to either (2) decreased ability of basal ganglia to detect violations of expectancy, (3) decreased ability of prefrontal cortex to respond to detected violations, or (4) decreased connectivity of the circuits. We are conducting three functional Magnetic Resonance Imaging (fMRI) studies to address these hypotheses.


Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Functional MRI of Cognitive Control in Autism

Further study details as provided by UMC Utrecht:

Estimated Enrollment: 90
Study Start Date: December 2007

Ages Eligible for Study:   6 Years to 12 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Aged 6 - 12 years at inclusion

Inclusion criteria for subjects with autism

  • DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview

Inclusion criteria for controls

  • No DSM-IV (APA, 1994) diagnosis, according to DISC interview
  • No scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  • IQ > 70

Exclusion Criteria:

  • Major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  • Presence of metal objects in or around the body (pacemaker, dental braces)
  • History of or present neurological disorder
  Contacts and Locations
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Please refer to this study by its identifier: NCT00463164

Contact: Sarah Durston, Ph.D. +31 30 250 8161

Dept. of Child and Adolescent Psychiatry, UMC Utrecht Not yet recruiting
Utrecht, Netherlands, 3584CX
Principal Investigator: Tamar van Raalten, M.Sc.         
Sponsors and Collaborators
UMC Utrecht
Principal Investigator: Sarah Durston, Ph.D. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
Study Chair: Herman van Engeland, M.D. Ph.D. Rudolf Magnust Institute of Neuroscience, UMC Utrecht
  More Information

Additional Information: Identifier: NCT00463164     History of Changes
Other Study ID Numbers: 06-179
Study First Received: April 19, 2007
Last Updated: April 19, 2007

Keywords provided by UMC Utrecht:
functional MRI

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders processed this record on September 19, 2017