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Slowing the Degenerative Process, Long Lasting Effect of Hyperbaric Oxygen Therapy in Retinitis Pigmentosa

This study has been completed.
Information provided by:
Azienda Policlinico Umberto I Identifier:
First received: April 17, 2007
Last updated: NA
Last verified: April 2007
History: No changes posted
Our aim was to assess the role and usefulness of Hyperbaric oxygen therapy in a long lasting period, assessing its efficacy on rescuing retinal photoreceptors and preserving visual function in retinitis pigmentosa.

Condition Intervention
Retinitis Pigmentosa
Procedure: hyperbaric oxygen therapy

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind
Official Title: Slowing the Degenerative Process, Long Lasting Effect of Hyperbaric Oxygen Therapy in Retinitis Pigmentosa

Resource links provided by NLM:

Further study details as provided by Azienda Policlinico Umberto I:


Ages Eligible for Study:   20 Years to 70 Years   (Adult, Senior)
Genders Eligible for Study:   Both

Inclusion Criteria:

  • Patients with clearly hereditary RP (we performed to all of them genetic analysis for rhodopsin, and peripherin genes, only 4 patient with ADRP showed point mutation 3 on codon 135 and 1 on codon 347); best corrected visual acuity (BCVA) ≥ 0.50 logMAR; visual field ≥ 3 degree diameter circle; recordable ERG.

Exclusion Criteria:

  • Exclusion criteria were: patients with sporadic RP; BCVA ≤ 0.50 logMAR; visual field ≤ 3 degree diameter circle; not recordable ERG.
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Please refer to this study by its identifier: NCT00461435

Azienda Policlinico Umberto I
Rome, Italy, 00161
Sponsors and Collaborators
Azienda Policlinico Umberto I
Principal Investigator: Enzo Maria Vingolo, PH.D. Policlinico Umberto I, Dipartimento di Oftalmologia
  More Information Identifier: NCT00461435     History of Changes
Other Study ID Numbers: SS01 
Study First Received: April 17, 2007
Last Updated: April 17, 2007
Health Authority: Italy:Italian National commitee for hyperbaric therapy

Additional relevant MeSH terms:
Retinitis Pigmentosa
Eye Diseases, Hereditary
Eye Diseases
Retinal Dystrophies
Retinal Degeneration
Retinal Diseases
Genetic Diseases, Inborn processed this record on December 02, 2016