Study of Thymopentin in Patients After Curative Resection of Small Hepatocellular Carcinoma
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|ClinicalTrials.gov Identifier: NCT00460681|
Recruitment Status : Unknown
Verified October 2007 by Fudan University.
Recruitment status was: Recruiting
First Posted : April 16, 2007
Last Update Posted : October 31, 2007
|Condition or disease||Intervention/treatment||Phase|
|Hepatocellular Carcinoma||Drug: Thymopentin||Phase 3|
Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies in China, and approximately 90% of the patients with HCC are also infected with hepatitis B virus (HBV).Chronic HBV infections are a leading cause of liver cirrhosis and hepatocellular carcinoma. Surgical resection provides a potentially curative outcome for patients who are indicated to this procedure; however, survival is far from satisfactory because of the high recurrence rate, which is approximately 38-65% during the first 5 years， even for small HCC resection , it is still as high as 43.5%，and contributed to the major cause of mortality. Several approaches have been reported to decrease the recurrence rate after curative resection of HCC, such as postoperative transcatheter arterial chemoembolization (TACE) , chemotherapy , cyclic retinoic acid , and adoptive immunotherapy . However, these approaches are either controversial or require further evaluation , a substantial need for novel treatments is required urgently.
Tumor-induced immuno-suppression leads to an imbalance within the immune system, which closely related to the HCC recurrence and metastasis after resection, and an effective response is needed to eliminate residual tumor cells after removal of the major tumor tissue by surgery. Immunomodulatory peptides, like thymopentin (TP5), may act as immunomodulatory agents in cancer chemotherapy. TP5 comprises the amino acids (Arg-Lys-Asp-Val-Tyr) and represents residues 32-36 of the nuclear protein thymopoietin (TP) . A multitude of in vivo studies have shown efficacy of TP5 treatment in the therapy of various diseases including neoplastic, immune deficiency, autoimmune, and recurrent viral diseases etc. It rectifies imbalances in the immune system without observable side effects, even at very high doses. Furthermore, TP5 is able to significantly inhibit proliferation and induce apoptosis in some type of cancer lines.
Thus TP5 can not only act as an immunomodulatory factor in cancer chemotherapy or anti-HBV therapy, but also has potential as a chemotherapeutic agent in human cancer therapy
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||220 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Phase III Study of Thymopentin in Patients After Curative Resection of Small|
|Study Start Date :||February 2007|
|Estimated Study Completion Date :||February 2012|
- disease-free survival [ Time Frame: three year ]
- overall survival [ Time Frame: three year ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00460681
|Contact: S J Qiu, MDemail@example.com|
|Liver Cancer Institute and Zhongshan Hospital, Fudan University||Recruiting|
|Shanghai, Shanghai, China, 200032|
|Contact: S J Qiu, MD +86-21-64037181 firstname.lastname@example.org|
|Study Director:||Jia Fan, MD||Liver Cancer Institute and Zhongshan Hospital, Fudan University, 200032, Shanghai, China.|