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Body Plethysmograph Measurements Before and After Methacholine Challenge in Early Childhood

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ClinicalTrials.gov Identifier: NCT00458627
Recruitment Status : Completed
First Posted : April 11, 2007
Last Update Posted : April 11, 2007
Information provided by:
Rambam Health Care Campus

Brief Summary:

In our previous study of Methacholine Challenge Tests (MCT) in preschool children, we found that wheeze detection was associated with significant reduction in flows and vital capacity values. We hypothesized that this finding is associated with trapped-air rather than the children's loss of cooperation/concentration.

Objectives: To test this hypothesis by attempting plethysmography measurements during MCT.

Condition or disease

  Show Detailed Description

Study Type : Observational
Estimated Enrollment : 50 participants
Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Prospective
Official Title: Body Plethysmograph Measurements Before and After Methacholine Challenge in Early Childhood
Study Start Date : February 2006
Estimated Study Completion Date : September 2006

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Ages Eligible for Study:   3 Years to 7 Years   (Child)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • 2.5-6.9 year-old children who were asthmatic according to GINA guidelines.
  • All children previously had recurrent episodes of wheeze, cough and/or shortness of breath with clinical response to bronchodilator.
  • Children were included only if they had not received anti-inflammatory medication for at least one week prior to the test or bronchodilators for at least 24 hours prior to the study.
  • On the day of testing, children were included if they had normal chest auscultation and FEV1>75% predicted for healthy preschool children.

Exclusion Criteria:

  • Presence of other chronic respiratory conditions
  • Emergency room visit in the past three months
  • Respiratory infection in the past month

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00458627

Sponsors and Collaborators
Rambam Health Care Campus
Principal Investigator: Lea Bentur, MD Rambam medical Center, Haifa, Israel
Principal Investigator: Daphna Vilozni, PhD Rambam Health Care Campus

ClinicalTrials.gov Identifier: NCT00458627     History of Changes
Other Study ID Numbers: 2044-CTIL
First Posted: April 11, 2007    Key Record Dates
Last Update Posted: April 11, 2007
Last Verified: April 2007

Keywords provided by Rambam Health Care Campus:
methacholine challenge

Additional relevant MeSH terms:
Methacholine Chloride
Autonomic Agents
Peripheral Nervous System Agents
Physiological Effects of Drugs
Bronchoconstrictor Agents
Respiratory System Agents
Muscarinic Agonists
Cholinergic Agonists
Cholinergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action