Hypothermia After In-hospital Cardiac Arrest (HACAinhospital)
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ClinicalTrials.gov Identifier: NCT00457431 |
Recruitment Status :
Terminated
(interim analysis with stopping for futility)
First Posted : April 6, 2007
Last Update Posted : June 22, 2021
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Condition or disease | Intervention/treatment | Phase |
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Cardiac Arrest | Procedure: Mild therapeutic hypothermia | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Actual Enrollment : | 249 participants |
Allocation: | Randomized |
Intervention Model: | Parallel Assignment |
Masking: | Single (Outcomes Assessor) |
Primary Purpose: | Treatment |
Official Title: | Hypothermia After In-hospital Cardiac Arrest |
Actual Study Start Date : | April 3, 2007 |
Actual Primary Completion Date : | November 9, 2014 |
Actual Study Completion Date : | March 1, 2021 |

Arm | Intervention/treatment |
---|---|
No Intervention: Control
Standard therapy as used in the hospital's ICU
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Active Comparator: Hypothermia
Standard therapy as used in the hospital's ICU plus Hypothermia
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Procedure: Mild therapeutic hypothermia
Mild therapeutic hypothermia will be performed by any methods applicable in the hospitals |
- all cause mortality at 6 months [ Time Frame: 6 months ]
- neurological outcome at six months measured by the Glasgow-Pittsburgh cerebral performance scale [ Time Frame: 6 months ]
- in-hospital all cause mortality [ Time Frame: time until discharge or death ]

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Ages Eligible for Study: | 18 Years and older (Adult, Older Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | No |
Inclusion Criteria:
- in-hospital cardiac arrest
- restoration of spontanous circulation
- unconsciousness
- age over 18
- initiation of mild therapeutic hypothermia is possible within 4h after resuscitation
Exclusion Criteria:
- active bleeding
- suspicion of intra cranial bleeding
- severe infection
- aquired immun deficency
- severe rhythm disorders
- suspicion of cerebral insult
- known severe cognotive deficit before the index event
- pregnancy
- pre existing disease which makes 6 months survival unlikely

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00457431
Germany | |
Sebastian Wolfrum | |
Lübeck, Schleswig-Holstein, Germany, 23538 |
Principal Investigator: | Sebastian Wolfrum, MD | University of Schleswig-Holstein, Campus Luebeck, Medical Clinic II |
Responsible Party: | Sebastian Wolfrum, D. Sebastian Wolfrum, University Hospital Schleswig-Holstein |
ClinicalTrials.gov Identifier: | NCT00457431 |
Other Study ID Numbers: |
HACA in-hospital |
First Posted: | April 6, 2007 Key Record Dates |
Last Update Posted: | June 22, 2021 |
Last Verified: | June 2021 |
in-hospital cardiac arrest resuscitation mild therapeutic hypothermia |
Heart Arrest Hypothermia Heart Diseases Cardiovascular Diseases Body Temperature Changes |