Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Coronary Artery Disease (HERCET-Study) (HERCET)
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|ClinicalTrials.gov Identifier: NCT00457379|
Recruitment Status : Unknown
Verified April 2007 by Hannover Medical School.
Recruitment status was: Recruiting
First Posted : April 6, 2007
Last Update Posted : August 15, 2007
Patients with coronary artery disease are characterized by an increased cardiovascular risk and they often have low blood high density lipoprotein (HDL)-cholesterol levels or HDL-cholesterol with modified vasculoprotective properties.
The purpose of the present study is to characterize the quality of HDL-cholesterol in patients with coronary artery disease and normal blood HDL-cholesterol levels and to examine the effect of exercise training on the vasculoprotective effects of HDL-cholesterol in these patients. Additionally, the researchers aim to investigate the endothelial function, oxidative stress and the regenerative capacity of the endothelial progenitor cells in patients with coronary artery disease and the changes dependent on physical activity of patients.
|Condition or disease||Intervention/treatment||Phase|
|Coronary Artery Disease||Behavioral: physical exercise||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||30 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Randomized, Clinical Trial to Study the Effect of Exercise Training on the Function of HDL-Cholesterol, Endothelial Function, Oxidative Stress and Regenerative Capacity of Endothelial Progenitor Cells in Patients With Coronary Artery Disease|
|Study Start Date :||April 2007|
|Estimated Study Completion Date :||April 2008|
- vasculoprotective and regenerative functions of HDL-cholesterol before and after 8-weeks of exercise training
- flow-mediated, endothelium-dependent vasodilation of radial artery measured by ultrasound
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00457379
|Contact: Ulf Landmesser, MD||+49511532 ext 2229||Landmesser.Ulf@MH-Hannover.de|
|Contact: Kristina Sonnenschein||+49511532 ext 5402||Sonnenschein.Kristina@MH-Hannover.de|
|Hannover Medical School||Recruiting|
|Hannover, Germany, 30625|
|Contact: Ulf Landmesser, MD +49511532 ext 2229 Ulf.Landmesser@MH-Hannover.de|
|Contact: Kristina Sonnenschein +49511532 ext 5402 Sonnenschein.Kristina@MH-Hannover.de|
|Principal Investigator: Ulf Landmesser, MD|
|Study Director:||Helmut Drexler, MD||Hannover Medical School|
|Principal Investigator:||Ulf Landmesser, MD||Hannover Medical School|
|Principal Investigator:||Kristina Sonnenschein, MD||Hannover Medical School|