Efficacy of Selegiline in Negative Symptoms of Schizophrenia
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|ClinicalTrials.gov Identifier: NCT00456976|
Recruitment Status : Completed
First Posted : April 5, 2007
Last Update Posted : July 23, 2008
Antipsychotic drugs are effective in treating the positive symptoms of schizophrenia; however their efficacy in treating negative symptoms is limited. This study wants to evaluate efficacy of selegiline augmentation of antipsychotic medication to treat negative symptoms in inpatients with chronic schizophrenia. With randomized clinical trial two groups of patients will select to receive selegiline or placebo.
Primary end point is decreasing in negative symptoms in case group. Inclusion criteria : 1- Patients with moderate to severe negative symptoms 2- Patients with at least one year antipsychotic drug therapy, at the current dose >= 1 month. 3- No other psychotropic drugs during past month. Exclusion criteria: 1- Severe major depressive disorder, substance abuse, severe positive symptoms of schizophrenia, Treatment of MDD with antidepressant drugs during past month.
|Condition or disease||Intervention/treatment||Phase|
|Schizophrenia||Drug: Selegiline||Early Phase 1|
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||70 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||Efficacy of Selegiline Augmentation of Antipsychotic Medication to Treat Negative Symptoms in Inpatients With Chronic Schizophrenia|
|Study Start Date :||April 2007|
|Estimated Study Completion Date :||September 2007|
- decreasing in negative symptoms in case group
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00456976
|Iran, Islamic Republic of|
|Razi university hospital|
|Tabriz, East Azarbaijan, Iran, Islamic Republic of, 5167846184|
|Study Chair:||Fatemeh Ranjbar Kouchaksaraei, Assistant Professor||Tabriz University of Medical Sciences|