Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity
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|ClinicalTrials.gov Identifier: NCT00456651|
Recruitment Status : Unknown
Verified April 2007 by Sociedad Española de Neumología y Cirugía Torácica.
Recruitment status was: Recruiting
First Posted : April 5, 2007
Last Update Posted : April 5, 2007
The hypothesis of the study is the following: Patients with sleep apnea-hypopnea syndrome have different pattern in the secretion of hormones.
The chronic sleep disorganization that suffer patients with sleep apnea-hypopnea syndrome (SAHS) may affect the central mechanisms that regulate nutritive behavior and energetic balance, causing an alteration in the secretion of hormones that favour the appearance and/or development of obesity.
|Condition or disease||Intervention/treatment||Phase|
|Sleep Apnea Obesity||Device: CPAP (Continuous Positive Airway Pressure)||Not Applicable|
OBJECTIVES: To compare the plasmatic profiles of different hormones and neuropeptides, related with weight control, metabolism and intake in patients with SAHS as well as in selected control subjects according to weight.
DESIGN: Multicenter, prospective and controlled study. 40 patients with SAHS will be included as well as 40 control subjects.
METHODS: To all subjects included in the study, the following procedures will be performed:
- Medical History;
- Anthropometric variables (height, weight, Body Mass Index;
- Somnolence evaluation using the Epworth scale;
- Conventional Polysomnography (PSG);
- Determination every four hours during a 24 hours period of the levels of leptin adiponectin, resistin, insulin, PCR, etc.
- Conventional biologic evaluation;
- Patients will be re-evaluated after three months of treatment with CPAP.
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||40 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Sleep Apnea-Hypopnea Syndrome and the Pathogenesis of Obesity|
|Study Start Date :||February 2007|
- OBJECTIVES: To compare the plasmatic profiles of different hormones
- and neuropeptides, related with weight control, metabolism and intake
- in patients with SAHS as well as in selected control subjects according
- to weight.
- CPAP (Continuous Positive Airway Pressure) effect on studied variables
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00456651
|Contact: Mónica de la Peña, MD||34 971 firstname.lastname@example.org|
|Hospital Universitario Son Dureta||Recruiting|
|Palma de Mallorca, Baleares, Spain, 07001|
|Principal Investigator:||Mónica de la Peña, MD||Hospital Universitario Son Dureta|