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Distal embolization can occur during coronary angioplasty performed in the acute phase of myocardial infarction and is associated with poor long-term outcome. We hypothesize that the use of a system allowing thrombus aspiration before angioplasty and stent implantation will limit infarct size and its severity.
Condition or disease
Ischemic Heart DiseaseAcute Myocardial Infarction
Device: Export Aspiration System
Patients scheduled for emergency angioplasty in the acute phase of a first ST-elevation myocardial infarction will be treated either by thromboaspiration followed by angioplasty or by angioplasty alone. The infarct size and severity will be assessed by ce-MRI and rest Tc99m-mibi gated SPECT performed during initial hospital stay (5th-8th day). A control MRI will be performed at 6-month follow-up to analyse the evolution of left ventricular volumes.
Infarct size and severity assessed by ce-MRI and rest Tc99m-mibi gated SPECT [ Time Frame: by ce-MRI and rest Tc99m-mibi gated SPECT ]
Secondary Outcome Measures :
Probability of evolution toward left ventricular remodelling (defined as an increase of end-diastolic volume of>20% between the acute phase and 6-montcontrol) [ Time Frame: of end-diastolic volumeof>20% between the acute phase and 6-montcontrol) ]
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
acute phase of myocardial infarction (>48 hours from the onset of chest pain)