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Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2006 by Medical University of Warsaw.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00453752
First Posted: March 29, 2007
Last Update Posted: March 29, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Medical University of Warsaw
  Purpose
The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Condition
Systemic Sclerosis

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by Medical University of Warsaw:

Estimated Enrollment: 100
Study Start Date: April 2006
Estimated Study Completion Date: April 2010
Detailed Description:
Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • Clinical diagnosis of systemic sclerosis

Exclusion Criteria:

  • Cardiovascular disorders other than pulmonary hypertension
  • Significant pulmonary function abnormalities
  • Impaired renal function
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00453752


Contacts
Contact: Ciurzyński Michał, M.D, Ph.D +48 22 502 11 44 mciurzyn@amwaw.edu.pl
Contact: Piotr Pruszczyk, M.D, Ph.D. +48 22 501 11 44 ppruszczyk@amwaw.edu.pl

Locations
Poland
Michał Ciurzyński Recruiting
Warsaw, Lindleya 4, Poland, 02-005
Contact: Michał Ciurzyński, M.D, Ph.D    +48 22 502 11 44    mciurzyn@amwaw.edu.pl   
Sponsors and Collaborators
Medical University of Warsaw
Investigators
Principal Investigator: Michał Ciurzyński, M.D., Ph.D Medical University of Warsaw
  More Information

ClinicalTrials.gov Identifier: NCT00453752     History of Changes
Other Study ID Numbers: KB/66/2006
First Submitted: March 28, 2007
First Posted: March 29, 2007
Last Update Posted: March 29, 2007
Last Verified: March 2006

Keywords provided by Medical University of Warsaw:
systemic sclerosis
pulmonary hypertension
echocardiography
N-Terminal proBNP

Additional relevant MeSH terms:
Sclerosis
Scleroderma, Systemic
Scleroderma, Diffuse
Pathologic Processes
Connective Tissue Diseases
Skin Diseases