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Non-Invasive Diagnostic and Functional Evaluation of Cardiac Involvement in Patients With Systemic Sclerosis

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2006 by Medical University of Warsaw.
Recruitment status was:  Recruiting
Information provided by:
Medical University of Warsaw Identifier:
First received: March 28, 2007
Last updated: NA
Last verified: March 2006
History: No changes posted
The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in systemic sclerosis patients and to establish whether it reflects the severity of RV overload.

Systemic Sclerosis

Study Type: Observational
Study Design: Observational Model: Defined Population
Primary Purpose: Screening
Time Perspective: Longitudinal
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Medical University of Warsaw:

Estimated Enrollment: 100
Study Start Date: April 2006
Estimated Study Completion Date: April 2010
Detailed Description:
Elevated serum brain natriuretic peptide (BNP) levels released from myocytes of ventricles upon stretch have been found in patients with isolated right ventricular (RV) pressure overload. However, limited data suggest that serum BNP may be elevated in patients with systemic sclerosis (SSc), especially with RV dysfunction. The aim of this study was to assess serum N-terminal proBNP (NT-proBNP) in SSc patients and to establish whether it reflects the severity of RV overload.

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes

Inclusion Criteria:

  • Clinical diagnosis of systemic sclerosis

Exclusion Criteria:

  • Cardiovascular disorders other than pulmonary hypertension
  • Significant pulmonary function abnormalities
  • Impaired renal function
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its identifier: NCT00453752

Contact: Ciurzyński Michał, M.D, Ph.D +48 22 502 11 44
Contact: Piotr Pruszczyk, M.D, Ph.D. +48 22 501 11 44

Michał Ciurzyński Recruiting
Warsaw, Lindleya 4, Poland, 02-005
Contact: Michał Ciurzyński, M.D, Ph.D    +48 22 502 11 44   
Sponsors and Collaborators
Medical University of Warsaw
Principal Investigator: Michał Ciurzyński, M.D., Ph.D Medical University of Warsaw
  More Information Identifier: NCT00453752     History of Changes
Other Study ID Numbers: KB/66/2006
Study First Received: March 28, 2007
Last Updated: March 28, 2007

Keywords provided by Medical University of Warsaw:
systemic sclerosis
pulmonary hypertension
N-Terminal proBNP

Additional relevant MeSH terms:
Scleroderma, Systemic
Scleroderma, Diffuse
Pathologic Processes
Connective Tissue Diseases
Skin Diseases processed this record on May 25, 2017