Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram
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|ClinicalTrials.gov Identifier: NCT00453700|
Recruitment Status : Unknown
Verified March 2007 by University of California, Los Angeles.
Recruitment status was: Recruiting
First Posted : March 29, 2007
Last Update Posted : March 29, 2007
Chagas disease is endemic to the Americas, infecting between 16-18 million individuals. In immigrant populations in the United States from endemic areas, it is estimated up to 4.9% may be asymptomatic carriers of Trypanosoma cruzi, the organism which causes Chagas disease. Between 10-20% of these patients progress to development of end-stage cardiomyopathy with a high associated morbidity. Following acute disease, patients enter into an indeterminate phase which can last 10-20 years. The earliest sign of cardiac involvement usually is electrocardiogram abnormalities. The most common abnormality is right bundle branch block (RBBB), followed by left anterior fascicular block (LAFB), and left bundle branch block (LBBB). Recent studies have shown that treatment of patients at this stage with antiparasitics may delay the progression of overt cardiomyopathy.
At the University of California, Los Angeles, there is a large population of immigrant patients from countries endemic to Chagas disease. The researchers propose that screening patients with conduction abnormalities on electrocardiogram may be a potentially useful method to identify patients with early cardiac manifestations of Chagas disease. The researchers hope to enroll approximately 300 individuals with RBBB, LAFB or LBBB on electrocardiogram to determine the incidence of Chagas disease in this patient population.
|Condition or disease||Intervention/treatment||Phase|
|Chagas Disease||Procedure: Trypanosoma cruzi serology||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Enrollment :||300 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||None (Open Label)|
|Official Title:||Prevalence of Chagas Disease in Immigrant Patients With Conduction Abnormalities on Electrocardiogram|
|Study Start Date :||February 2007|
- Prevalence of positive trypanosoma cruzi serologies
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00453700
|Contact: Sheba K Meymandi, M.D.||firstname.lastname@example.org|
|Contact: Mahmoud I Traina, M.D.||email@example.com|
|United States, California|
|OV-UCLA Medical Center||Recruiting|
|Sylmar, California, United States, 91342|
|Principal Investigator:||Sheba K Meymandi, M.D.||OV-UCLA Medical Center|