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Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00452998
First Posted: March 28, 2007
Last Update Posted: May 14, 2008
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
National University Hospital, Singapore
  Purpose
Sequential Laser Iridotomy uses argon and Nd:yag laser in the first and second steps, respectively. Using q-switched 532 nm laser in the second step is hypothesized to be as good and effective as the conventional Nd:yag laser, because it selectively targets pigmented cells and delivers a short pulse duration of 3 nanoseconds, causing less thermal and collateral damage.

Condition Intervention
Chronic Angle Closure Glaucoma Primary Angle Closure Primary Angle Closure Suspect Fellow Eyes of Acute Angle Closure Glaucoma Procedure: Q-switched fd Nd:yag in Laser Iridotomy

Study Type: Interventional
Study Design: Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Sequential Laser Iridotomy Using Argon and Q-Switched 532 nm Frequency Doubled Neodymium Yag Laser: A Pilot Study

Resource links provided by NLM:


Further study details as provided by National University Hospital, Singapore:

Primary Outcome Measures:
  • Visual Acuity
  • Intraocular pressure
  • Total power delivered by each laser modality
  • Iridotomy patency and size
  • Pain rating during the procedure
  • Anterior segment inflammation
  • Endothelial cell count
  • Cataract progression
  • Rate of complications

Estimated Enrollment: 10
Study Start Date: November 2006
Study Completion Date: December 2007
Primary Completion Date: December 2007 (Final data collection date for primary outcome measure)
  Show Detailed Description

  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   22 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  • More than 21 years old
  • Able to give informed consent
  • Diagnosis of either: chronic angle closure glaucoma (CACG), primary angle closure (PAC), primary angle closure suspect (PACS) or fellow eyes of acute angle closure glaucoma (AACG), and in need of a laser iridotomy

Exclusion Criteria:

  • History of any prior laser treatment or intraocular surgery to the eye
  • History of any corneal disease
  • Any ocular infection/ inflammation within the last two months
  • Inability to give informed consent
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00452998


Locations
Singapore
National University Hospital
Singapore, Singapore, 119074
Sponsors and Collaborators
National University Hospital, Singapore
Investigators
Principal Investigator: Paul Chew, FRCSEd,MMed National University Hospital, Singapore
  More Information

Publications:
Responsible Party: Cecilia Aquino, MD, National University Hospital, Singapore
ClinicalTrials.gov Identifier: NCT00452998     History of Changes
Other Study ID Numbers: DSRB A/06/293
First Submitted: March 27, 2007
First Posted: March 28, 2007
Last Update Posted: May 14, 2008
Last Verified: May 2008

Keywords provided by National University Hospital, Singapore:
Sequential Laser Iridotomy
Q-Switched 532 nm Laser
Frequency Doubled Neodymium Yag Laser

Additional relevant MeSH terms:
Glaucoma
Glaucoma, Angle-Closure
Acute Disease
Ocular Hypertension
Eye Diseases
Disease Attributes
Pathologic Processes