The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
Sickle cell disease is an inherited blood disorder that affects red blood cells (RBCs). People with sickle cell disease frequently experience anemia, or a low number of RBCs. RBCs are responsible for carrying oxygen to the brain and other body tissues that need oxygen to function properly. The purpose of this study is to determine what changes, which were possibly caused by anemia, exist in the brains of individuals with sickle cell disease.
Sickle Cell Disease
|Official Title:||Sickle-Cell Disease: Neuroimaging and Cognitive Decline|
|Study Start Date:||July 2006|
The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.
Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00451919
|Contact: Randall R. Rule, PhD||415-221-4810 ext firstname.lastname@example.org|
|Contact: Jeffrey Kasten||415-221-4810 ext email@example.com|
|United States, California|
|University of California San Francisco||Recruiting|
|San Francisco, California, United States, 94121|
|Contact: Randall R. Rule, PhD 415-221-4810 ext 4830 firstname.lastname@example.org|
|Contact: Jeffrey Kasten 415-221-4810 ext 2030 email@example.com|
|Principal Investigator: Randall R. Rule, PhD|
|Principal Investigator:||Randall R. Rule, PhD||University of California, San Francisco|