The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00451919|
Recruitment Status : Completed
First Posted : March 26, 2007
Last Update Posted : August 19, 2016
|Condition or disease|
|Sickle Cell Disease|
The role of RBCs is to carry oxygen from the lungs to the brain and other body tissues. Individuals with anemia have unusually low numbers of RBCs. They also often have difficulty concentrating and remembering information, which is likely caused by a reduced oxygen supply to the brain. Previous research has shown that correcting anemia in patients without sickle cell disease improved their memory and attention. The purpose of this study is to examine any abnormal changes in the brains of individuals with sickle cell disease and to determine whether these changes are related to reduced memory and attention capabilities.
Participants will attend one study visit. During this visit, a brain magnetic resonance image (MRI) will be performed while participants complete neuropsychological tests that measure memory, attention, and organizational ability. There will be no follow-up visits.
The study completion date listed in this record was obtained from the "End Date" entered in the Protocol Registration and Results System (PRS) record.
|Study Type :||Observational|
|Actual Enrollment :||120 participants|
|Official Title:||Sickle-Cell Disease: Neuroimaging and Cognitive Decline|
|Study Start Date :||July 2006|
|Actual Primary Completion Date :||February 2009|
|Actual Study Completion Date :||February 2009|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00451919
|United States, California|
|University of California San Francisco|
|San Francisco, California, United States, 94121|
|Principal Investigator:||Randall R. Rule, PhD||University of California, San Francisco|