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Cortisol in the Treatment of Phobias

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00451750
First Posted: March 23, 2007
Last Update Posted: January 12, 2010
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Collaborator:
University Hospital, Basel, Switzerland
Information provided by:
University of Zurich
  Purpose
The aim of this prospective, double-blind, placebo-controlled, randomized study is to investigate if glucocorticoid treatment, in combination with exposure therapy, helps to reduce phobic fear in patients with phobia.

Condition Intervention
Phobia Drug: Cortisol

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
Primary Purpose: Treatment
Official Title: The Efficacy of Cortisol in Combination With Behavioral Therapy in the Treatment of Phobias

Resource links provided by NLM:


Further study details as provided by University of Zurich:

Primary Outcome Measures:
  • visual analog scales for fear and acrophobia questionnaires [ Time Frame: 1 month ]

Estimated Enrollment: 40
Study Start Date: May 2007
Study Completion Date: September 2009
Primary Completion Date: September 2009 (Final data collection date for primary outcome measure)
Intervention Details:
    Drug: Cortisol
    20 mg for 3 times
  Eligibility

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 55 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

- Female and male patients with a specific phobia (fear of heights) according to DSM-IV criteria.

Exclusion Criteria:

  • Severe acute or chronic somatic diseases
  • Psychiatric disorder other than specific phobia
  • Topic glucocorticoid therapy (for large skin parts)
  • Inhaled glucocorticoids
  • Psychotropic medication
  • Pregnancy
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00451750


Locations
Switzerland
University of Basel
Basel, Switzerland, 4055
Sponsors and Collaborators
University of Zurich
University Hospital, Basel, Switzerland
Investigators
Principal Investigator: Dominique JF de Quervain, MD, Prof. University of Zurich
Principal Investigator: Frank Wilhelm, Prof. University of Basel
  More Information

Publications:
Responsible Party: Dominique de Quervain, Prof. MD, University of Zurich
ClinicalTrials.gov Identifier: NCT00451750     History of Changes
Other Study ID Numbers: 2007DR3069
First Submitted: March 21, 2007
First Posted: March 23, 2007
Last Update Posted: January 12, 2010
Last Verified: January 2010

Keywords provided by University of Zurich:
phobia
cortisol
memory
treatment

Additional relevant MeSH terms:
Phobic Disorders
Anxiety Disorders
Mental Disorders
Hydrocortisone 17-butyrate 21-propionate
Hydrocortisone acetate
Cortisol succinate
Hydrocortisone
Anti-Inflammatory Agents