The Effect of Agomelatine or Fluoxentine on Heart Rate Variability in Patients With Major Depressive Disorder
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ClinicalTrials.gov Identifier: NCT00451490
Recruitment Status :
(This study not get the approval by the drug company)
Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both agomelatine and floxentine will increase HRV at the end of the treatment.
Condition or disease
Depressive Disorder, Major
Drug: AgomelatineDrug: Fluoxentine
Phase advance of HRV will be anticipated in agomelatine group. It is anticipated that both agomelatine and floxentine will have equal efficacy in improvement of depressive symptoms and increasement of HRV at the end of the treatment.
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Layout table for eligibility information
Ages Eligible for Study:
18 Years to 65 Years (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Male or female
18 to 65 years outpatients
DSM-IV-TR criteria for Major Depressive Disorder
Patients with cardiac conditions and other physical conditions contraindicated for drug study
Patients known to be non-responders to fluoxetine treatment