Metabolic Effects of Cocaine

This study has been completed.
National Alliance for Research on Schizophrenia and Depression
Information provided by:
National Institute on Drug Abuse (NIDA) Identifier:
First received: March 22, 2007
Last updated: April 30, 2013
Last verified: October 2002
The goal of this this study is to elucidate the role of the HPA axis in the pathophysiology of cocaine dependence

Condition Intervention
Cocaine Dependence
Drug: cocaine
Drug: hydrocortisone

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Single Group Assignment
Masking: Double-Blind
Official Title: Elucidating the Role of the Hypothalamic-Pituitary-Adrenal (HPA) Axis in the Mechanisms Underlying Cocaine Dependence

Resource links provided by NLM:

Further study details as provided by National Institute on Drug Abuse (NIDA):

Estimated Enrollment: 15

Ages Eligible for Study:   21 Years to 49 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Individuals with DSM IV diagnosis of cocaine dependence, medically healthy

Exclusion Criteria:

  • Other than cocaine dependence DSM-IV axis I diagnosis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00451230

United States, Massachusetts
Massachusetts General Hospital
Boston, Massachusetts, United States, 02116
Sponsors and Collaborators
National Institute on Drug Abuse (NIDA)
National Alliance for Research on Schizophrenia and Depression
Principal Investigator: Igor Elman MGH
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00451230     History of Changes
Other Study ID Numbers: 2000p 000323  DA#14410 
Study First Received: March 22, 2007
Last Updated: April 30, 2013
Health Authority: United States: Federal Government

Keywords provided by National Institute on Drug Abuse (NIDA):
craving, insulin, leptin

Additional relevant MeSH terms:
Cocaine-Related Disorders
Chemically-Induced Disorders
Mental Disorders
Substance-Related Disorders
Anesthetics, Local
Anti-Inflammatory Agents
Central Nervous System Depressants
Dopamine Agents
Dopamine Uptake Inhibitors
Membrane Transport Modulators
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Neurotransmitter Uptake Inhibitors
Peripheral Nervous System Agents
Physiological Effects of Drugs
Sensory System Agents
Vasoconstrictor Agents processed this record on May 26, 2016