Kinetics of D-Dimers After Abdominal Surgery
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|ClinicalTrials.gov Identifier: NCT00450528|
Recruitment Status : Completed
First Posted : March 22, 2007
Last Update Posted : October 24, 2007
|Condition or disease|
|Natural Kicetics of d-Dimers After Surgery|
Venous thromboembolism (VTE) is a potentially fatal disease with an estimated incidence of 0.1%. One third of the VTE occur as pulmonal embolism with a mortality up to 25% (White RH. Circulation 107:2003)
Serum d-dimer levels are used as sensitive marker for the diagnosis of VTE (Kelly J et al. Arch Intern Med, 162: 2002). Because of its sensitivity, the determination of serum D-dimer levels is an accepted method to exclude VTE in the outpatient setting meaning that VTE may be excluded in case of normal D-dimer levels (Kelly J. Lancet 359: 2002). The specificity of the D-dimer testing, however, is low. This is true especially in the postoperative phase. The interpretation of elevated D-dimer levels in surgical patients remains elusive.
The natural kinetics of D-dimers after surgery is not known. The question to what extent D-dimer levels rise after surgery and how long it may take D-dimer levels to return to normal after surgery is not yet determined. This information is needed to be able to use D-dimer testing for VTE diagnosis in surgical patients.
In this study, D-dimer levels are measured in surgical patients immediately before (day 0) and repeatedly after surgery. D-dimer level measurement will be stopped after D-dimer levels returned to normal.
|Study Type :||Observational|
|Estimated Enrollment :||90 participants|
|Official Title:||The Kinetics of D-Dimers After Abdominal Surgery as a Function of the Invasiveness of Surgery|
|Study Start Date :||February 2007|
|Actual Study Completion Date :||October 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00450528
|Univeryity Hospital, Clinic for Visceral- and Transplantation Surgery|
|Zurich, Switzerland, 8091|
|Principal Investigator:||Daniel Dindo, MD||University of Zurich|