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Comparison of Cardiac Computed Tomographic Angiography (CTA) to Tc-99m Single Photon Emission Computed Tomography (SPECT)

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ClinicalTrials.gov Identifier: NCT00449943
Recruitment Status : Completed
First Posted : March 21, 2007
Last Update Posted : January 26, 2012
Sponsor:
Information provided by (Responsible Party):
Benjamin Chow, Ottawa Heart Institute Research Corporation

Brief Summary:

Cardiovascular disease and ischemic heart disease is the #1 killer in Canada. Currently, Cardiac invasive catheterization angiography (CICA) is the gold standard for the assessment of the arteries in the heart. However, cardiac catheterization has risks which prohibit its use in all patients. These risks include: death, heart attack, stroke and bleeding. Cardiac computed tomography angiography (CTA) is a new non-invasive technology which may enable the evaluation of patients' coronary anatomy without exposing patients to the risks of invasive cardiac catheterization.

The purpose of this project is to compare CT angiography (CTA) to Tc-99m single photon emission computed tomography (Tc-99m SPECT)

We will enroll patients who are waiting for a CICA or who have been referred for a TC-99m SPECT or CTA scans at the University of Ottawa Heart Institute. Consenting patients who are waiting for a CICA will have both a CTA and a Tc-99m SPECT scan. Consenting patients referred for a CTA or Tc-99m SPECT will have both the CTA and Tc-99m SPECT in a random order but not CICA (unless ordered by your physician).


Condition or disease Intervention/treatment Phase
Coronary Artery Disease Procedure: Computed Tomographic Angiography Procedure: Myocardial Perfusion Imaging Scan Not Applicable

Study Type : Interventional  (Clinical Trial)
Actual Enrollment : 107 participants
Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Diagnostic
Official Title: Comparison of Cardiac Computed Tomographic Angiography (CTA) to Tc-99m Single Photon Emission Computed Tomography (SPECT)
Study Start Date : September 2006
Actual Primary Completion Date : December 2008
Actual Study Completion Date : December 2010

Resource links provided by the National Library of Medicine

MedlinePlus related topics: CT Scans


Intervention Details:
  • Procedure: Computed Tomographic Angiography
    CT scan
  • Procedure: Myocardial Perfusion Imaging Scan
    SPECT


Primary Outcome Measures :
  1. To measure the accuracy of CTA to SPECT for the diagnosis of CAD [ Time Frame: 1 year ]

Secondary Outcome Measures :
  1. To examine the accuracy of CTA predicting the mode of treatment: Medical therapy or revascularization (PCI versus CABG) [ Time Frame: 1 year ]


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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Patients referred for Tc-99m SPECT or CTA; or
  • Patients referred for CICA without preceding (< 12 months) MPI or CTA

Exclusion Criteria:

  • Previous revascularization (PCI or CABG)
  • Age < 18 years or lack of consent
  • Renal Insufficiency (GFR < 60 ml/min)
  • Allergy or contraindication to contrast agent or dipyridamole
  • Refractory angina requiring urgent/emergent coronary angiography
  • Contraindication to radiation exposure (e.g. pregnancy)
  • Uncontrolled HR
  • Atrial fibrillation, frequent atrial or ventricular ectopy (> 1/minute)
  • Unable to perform 10 second breath-hold

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00449943


Locations
Canada, Ontario
University of Ottawa Heart Institute
Ottawa, Ontario, Canada, K1Y 4W7
Sponsors and Collaborators
Ottawa Heart Institute Research Corporation
Investigators
Principal Investigator: Benjamin JW Chow, MD, FRCPC Ottawa Heart Institute Research Corporation
Study Chair: Robert Beanlands, MD Ottawa Heart Institute Research Corporation
Study Chair: Terrence Ruddy, MD Univeristy of Ottawa Heart Institute
Study Chair: Carole Dennie, MD The Ottawa Hospital

Additional Information:
Responsible Party: Benjamin Chow, MD, Ottawa Heart Institute Research Corporation
ClinicalTrials.gov Identifier: NCT00449943     History of Changes
Other Study ID Numbers: 2006360-01H
First Posted: March 21, 2007    Key Record Dates
Last Update Posted: January 26, 2012
Last Verified: January 2012

Keywords provided by Benjamin Chow, Ottawa Heart Institute Research Corporation:
Cardiac Invasive Catheterization Angiography
Single Photon Emission Computed Tomography
Computed Tomography Angiography

Additional relevant MeSH terms:
Coronary Artery Disease
Myocardial Ischemia
Coronary Disease
Heart Diseases
Cardiovascular Diseases
Arteriosclerosis
Arterial Occlusive Diseases
Vascular Diseases