Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)
|The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.|
|ClinicalTrials.gov Identifier: NCT00449826|
Recruitment Status : Completed
First Posted : March 21, 2007
Last Update Posted : January 26, 2012
The purpose of this project is to examine the effectiveness of computed tomographic angiography (CTA) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). People who are hospitalized with this situation often require an angiogram to assess the heart and its arteries.
Recent advancements in technology have enabled CTA to clearly define coronary artery anatomy with great accuracy and to guide treatment strategies in select patient populations. We are investigating that CTA may be used, as an alternative to conventional angiograms, for the risk stratification of patients with high risk NSTE-ACS.
Patients eligible for the study will be high risk NSTE-ACS and awaiting an angiogram. Enrolled patients will undergo CTA prior to the angiogram. With each CTA the patient will be injected with a small dose of an X-ray dye and will be asked to lie still on the "scanning bed" for a period of 5-10 minutes.
|Condition or disease||Intervention/treatment||Phase|
|Acute Coronary Syndrome Non-ST-Elevation Myocardial Infarction Unstable Angina||Procedure: Computed Tomographic Angiography||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||107 participants|
|Intervention Model:||Single Group Assignment|
|Masking:||Single (Outcomes Assessor)|
|Official Title:||Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)|
|Study Start Date :||September 2006|
|Actual Primary Completion Date :||December 2008|
|Actual Study Completion Date :||December 2010|
- Procedure: Computed Tomographic Angiography
- Operating Characteristics of CTA [ Time Frame: 1 month ]
- To compare the accuracy of CTA to CICA in predicting the mode of revascularization (PCI versus CABG) in NSTE-ACS patients. [ Time Frame: 1 month ]
- To determine the number of "avoidable" CICA (i.e. those accurately designated to medical therapy or surgery with CTA). [ Time Frame: 1 month ]
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00449826
|University of Ottawa Heart Institute|
|Ottawa, Ontario, Canada, K1Y 4W7|
|Study Director:||Carole Dennie, MD||The Ottawa Hospital|
|Study Director:||Derek So, MD||Ottawa Heart Institute Research Corporation|
|Study Director:||Chris Glvoer, MD||Univeristy of Ottawa Heart Institute|
|Principal Investigator:||Benjamin JW Chow, MD||Ottawa Heart Institute Research Corporation|