Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)
The purpose of this project is to examine the effectiveness of computed tomographic angiography (CTA) in patients with non-ST elevation acute coronary syndrome (NSTE-ACS). People who are hospitalized with this situation often require an angiogram to assess the heart and its arteries.
Recent advancements in technology have enabled CTA to clearly define coronary artery anatomy with great accuracy and to guide treatment strategies in select patient populations. We are investigating that CTA may be used, as an alternative to conventional angiograms, for the risk stratification of patients with high risk NSTE-ACS.
Patients eligible for the study will be high risk NSTE-ACS and awaiting an angiogram. Enrolled patients will undergo CTA prior to the angiogram. With each CTA the patient will be injected with a small dose of an X-ray dye and will be asked to lie still on the "scanning bed" for a period of 5-10 minutes.
|Acute Coronary Syndrome Non-ST-Elevation Myocardial Infarction Unstable Angina||Procedure: Computed Tomographic Angiography|
|Study Design:||Allocation: Non-Randomized
Intervention Model: Single Group Assignment
Masking: Single (Outcomes Assessor)
Primary Purpose: Diagnostic
|Official Title:||Risk Stratification of Non ST Elevation ACS With Computed Tomographic Angiography (REACT)|
- Operating Characteristics of CTA [ Time Frame: 1 month ]
- To compare the accuracy of CTA to CICA in predicting the mode of revascularization (PCI versus CABG) in NSTE-ACS patients. [ Time Frame: 1 month ]
- To determine the number of "avoidable" CICA (i.e. those accurately designated to medical therapy or surgery with CTA). [ Time Frame: 1 month ]
|Study Start Date:||September 2006|
|Study Completion Date:||December 2010|
|Primary Completion Date:||December 2008 (Final data collection date for primary outcome measure)|
Procedure: Computed Tomographic Angiography
Please refer to this study by its ClinicalTrials.gov identifier: NCT00449826
|University of Ottawa Heart Institute|
|Ottawa, Ontario, Canada, K1Y 4W7|
|Study Director:||Carole Dennie, MD||The Ottawa Hospital|
|Study Director:||Derek So, MD||Ottawa Heart Institute Research Corporation|
|Study Director:||Chris Glvoer, MD||Univeristy of Ottawa Heart Institute|
|Principal Investigator:||Benjamin JW Chow, MD||Ottawa Heart Institute Research Corporation|