Multidrug Resistance After Trabeculectomy With Mitomycin C

This study has been completed.
Information provided by:
University of Cologne Identifier:
First received: March 19, 2007
Last updated: March 23, 2007
Last verified: March 2007
We investigate whether mitomycin C treatment during previous filtration surgery induces P-glycoprotein expression.


Study Type: Observational
Study Design: Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Multidrug Resistance After Trabeculectomy With Mitomycin C

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Further study details as provided by University of Cologne:

Estimated Enrollment: 30
Detailed Description:
Despite the adjuvant use of mitomycin C during trabeculectomy, short-term and long-term failures still occur. We investigate whether mitomycin C treatment during previous trabeculectomy induces P-glycoprotein expression. Expression of P-glycoprotein is analysed in surgically removed Tenon tissue using immunohistochemistry.

Ages Eligible for Study:   8 Years to 85 Years
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • patients with planned trabeculectomy for elevated eye pressure
  • one third of patients without previous trabeculectomy
  • two thirds of patients with previous trabeculectomy (one third with and one third without the use of mitomycin C)

Exclusion Criteria:

  • patients not requiring surgery
  • patients with planned surgery for elevated eye pressure other than trabeculectomy
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Please refer to this study by its identifier: NCT00449631

The University Hospital of Cologne
Cologne, Germany, 50924
Sponsors and Collaborators
University of Cologne
Principal Investigator: Arno Hueber, MD University of Cologne
  More Information

No publications provided by University of Cologne

Additional publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00449631     History of Changes
Other Study ID Numbers: Multidrug Resistance
Study First Received: March 19, 2007
Last Updated: March 23, 2007
Health Authority: Germany: Federal Institute for Drugs and Medical Devices

Keywords provided by University of Cologne:
Drug Resistance, Multiple
Trabeculectomy processed this record on November 27, 2015