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Magnetic Resonance Imaging of Brain Development in Autism

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified March 2007 by UMC Utrecht.
Recruitment status was:  Recruiting
Sponsor:
ClinicalTrials.gov Identifier:
NCT00449566
First Posted: March 20, 2007
Last Update Posted: March 20, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
UMC Utrecht
  Purpose
The purpose of this study is to investigate brain development in autism by longitudinally assessing children with autism, as well as typically developing controls, using advanced MR techniques. We will use longitudinal diffusion tensor imaging (DTI) measures to investigate the protracted development of long-range white matter fibers in autism. In addition, we will investigate the effect of autism risk genes on brain development.

Condition
Autism

Study Type: Observational
Study Design: Observational Model: Case Control
Observational Model: Natural History
Time Perspective: Longitudinal
Time Perspective: Prospective
Official Title: Magnetic Resonance Imaging of Brain Development in Autism

Resource links provided by NLM:


Further study details as provided by UMC Utrecht:

Estimated Enrollment: 300
Study Start Date: January 2006
  Eligibility

Information from the National Library of Medicine

Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the contacts provided below. For general information, Learn About Clinical Studies.


Ages Eligible for Study:   6 Years to 18 Years   (Child, Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Criteria

Inclusion Criteria:

  1. Aged 6 - 18 years at initial MRI

Inclusion criteria for subjects with autism

1) DSM-IV (APA, 1994) diagnosis of autism, according to ADI-R interview

Inclusion criteria for controls

  1. no DSM-IV (APA, 1994) diagnosis, according to DISC interview
  2. no scores in the clinical range on the Child Behavior Checklist (CBCL) and Teacher Rating Form (TRF)
  3. IQ > 70

Exclusion Criteria:

  1. major illness of the cardiovascular, the endocrine, the pulmonal or the gastrointestinal system
  2. presence of metal objects in or around the body (pacemaker, dental braces)
  3. history of or present neurological disorder
  4. for individuals over 12 years of age: legal incompetence, defined as the obvious inability to comprehend the information that is presented by the investigator and is outlined in the Information letter and on which the decision to participate in the study is to be based
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00449566


Contacts
Contact: Sarah Durston +31 30 250 8161 S.Durston@umcutrecht.nl

Locations
Netherlands
Dept. of Child and Adolescent Psychiatry, UMC Utrecht Recruiting
Utrecht, Netherlands, 3584CX
Contact: Marieke Langen, M.Sc.    +31 30 250 7084    M.Langen@umcutrecht.nl   
Principal Investigator: Marieke Langen, M.Sc.         
Principal Investigator: Hilde Nederveen, M.Sc.         
Sponsors and Collaborators
UMC Utrecht
Investigators
Principal Investigator: Sarah Durston, Ph.D. Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht
Study Chair: Herman van Engeland, M.D. Ph.D. Rudolf Magnust Institute of Neuroscience, UMC Utrecht
  More Information

Additional Information:
Publications:
ClinicalTrials.gov Identifier: NCT00449566     History of Changes
Other Study ID Numbers: METC 05/208-K
First Submitted: March 18, 2007
First Posted: March 20, 2007
Last Update Posted: March 20, 2007
Last Verified: March 2007

Keywords provided by UMC Utrecht:
Magnetic Resonance Imaging
Diffusion Tensor Imaging

Additional relevant MeSH terms:
Autistic Disorder
Child Development Disorders, Pervasive
Neurodevelopmental Disorders
Mental Disorders