Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques
Lipid-rich atherosclerotic plaques, or "vulnerable plaques" are prone to rupture, causing local intravascular thrombosis, with subsequent grave clinical consequences. Atherosclerotic plaques normally removed during surgery, and peripheral blood samples will be studied to achieve the following objectives:
"1" Define histological features of the vulnerable plaque, analyze its physical characteristics, and investigate selected gene expression.
"2" Study biomarkers of inflammation in conjunction with the presence of vulnerable plaques.
"3" Explore the potential role of infection in atherogenesis.
Peripheral Vascular Diseases
|Study Design:||Observational Model: Case Control
Time Perspective: Cross-Sectional
|Official Title:||Physical,Histological,and Genetic Analyses of Lipid-rich Atherosclerotic Plaques|
- To uncover mechanisms of cardiovascular diseases [ Time Frame: 3 years ] [ Designated as safety issue: No ]
Biospecimen Retention: Samples Without DNA
|Study Start Date:||March 2001|
|Estimated Study Completion Date:||July 2018|
|Estimated Primary Completion Date:||July 2017 (Final data collection date for primary outcome measure)|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00449306
|Sheba Medical Center, Tel Hashomer|
|Ramat Gan, Israel, 52621|
|Principal Investigator:||Jacob Schneiderman, MD||Department of Vascular Surgery, Sheba Medical Center, Tel Hashomer|