The Effect of Intensive Insulin Therapy
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|ClinicalTrials.gov Identifier: NCT00447239|
Recruitment Status : Completed
First Posted : March 14, 2007
Last Update Posted : October 24, 2008
Aim. To determine whether the maintenance of normoglycemia decreases the incidence of ventilator associated pneumonia (VAP), reduces its treatment period and the length of stay in the intensive care unit.
Methods. Prospective, randomized, controlled trial. We enrolled 117 mechanically ventilated trauma (71) and abdominal (46) surgical patients, older than 18, of both sex. In 57 patients (strict glucose control group) we aimed to maintain the blood glucose level between 4.4 and 6. 1 mmol/L, while in 60 patients (standard glucose control group) it was maintained between 7.8 and 10.0 mmol/L, with the use of continues insulin infusion. Insulin dose adjustments were based on measurements of glucose in capillary blood sample.
Key words: surgical patients; mechanical ventilation; pneumonia; blood glucose; insulin infusion; hospital stay
|Condition or disease||Intervention/treatment|
|the Maintenance of Normoglycemia the Incidence of Ventilator Associated Pneumonia (VAP) Treatment Period in the Intensive Care Unit||Procedure: glucontrol (insulin therapy)|
University Medical Centre Ljubljana has indicated that access to an investigational treatment associated with this study is available outside the clinical trial.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||117 participants|
|Intervention Model:||Parallel Assignment|
|Official Title:||The Effect of Intensive Insulin Therapy on the Incidence of Ventilator-Associated Pneumonia in Surgical Critically Ill Patients|
|Study Start Date :||September 2004|
|Estimated Study Completion Date :||July 2006|
- measurements of glucose in capillary blood sample
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00447239
|Clinical Centre Ljubljana|
|Ljubljana, Slovenia, 1000|
|Principal Investigator:||Adela Stecher||Clinical Centre Ljubljana|