Combination Therapy for Neovascular Age Related Macular Degeneration
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|ClinicalTrials.gov Identifier: NCT00447031|
Recruitment Status : Withdrawn (Insufficient patients who met inclusion criteria)
First Posted : March 13, 2007
Last Update Posted : February 9, 2010
Exudative age related macular degeneration (ARMD) is most common cause of blindness in old population. It is clear that no single therapy addresses the multifactorial pathogenesis of the disease. Recently, studies of intravitreal anti-VEGF therapies such as pegaptanib and bevacizumab have shown the beneficial effect in visual acuity in the treatment of neovascular ARMD. However, the problem with these intravitreal injections is that therapy must be frequently administered for a prolonged but unknown period of time to maintain the benefit. Prolonged, frequent injections may be associated with additional safety risk,lack of convenience and high treatment cost.
Intravitreal steroid injection with anti-inflammatory properties limits any further VEGF upregulation initiated by the inflammation which has been known as one of the pathogenesis and causes of recurrence after the treatment of the neovascular ARMD.
The researchers hypothesize that the combined treatment of intravitreal bevacizumab and triamcinolone acetonide may decrease the recurrence rate after the treatment and obviate the frequent intravitreal injections in the treatment of neovascular ARMD.
In this study, the researchers will compare the recurrence rate of combined treatment of intravitreal bevacizumab and triamcinolone acetonide versus intravitreal bevacizumab alone in the treatment of neovascular ARMD.
|Condition or disease||Intervention/treatment||Phase|
|Macular Degeneration||Drug: intravitreal bevacizumab and triamcinolone acetonide||Not Applicable|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Intravitreal Bevacizumab Combined With Intravitreal Triamcinolone Acetonide Injection Versus Intravitreal Bevacizumab for Age Related Macular Degeneration|
|Study Start Date :||March 2007|
|Estimated Study Completion Date :||November 2007|
- recurrence rate
- best corrected visual acuity
- complication rate
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00447031
|Korea, Republic of|
|Department of Ophthalmology, Yonsei University College of Medicine|
|Seoul, Korea, Republic of, 120-752|
|Principal Investigator:||Hyoung Jun Koh||YUMC|