CPAP Versus NPPV in ACPE
|ClinicalTrials.gov Identifier: NCT00446498|
Recruitment Status : Completed
First Posted : March 13, 2007
Last Update Posted : April 3, 2007
|Condition or disease||Intervention/treatment||Phase|
|Pulmonary Edema||Device: CPAP and Non Invasive Ventilation||Phase 4|
Background Although non-invasive ventilation has shown to be an effective treatment for acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised prospective studies that compares CPAP with NPPV.
Aim of the study was to assess efficacy and safety of CPAP and NPPV in patients with ACPO.
Methods 80 patients with ACPO were randomly assigned to receive CPAP or NPPV (40 for each group) through a face mask.
Inclusion criteria were: severe dyspnoea, respiratory rate > 30, PaO2/FiO2 < 200, muscle fatigue.
Main end-points were endotracheal intubation, length of ventilation, hospital length of stay and mortality.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||80 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial.|
|Study Start Date :||July 2002|
|Study Completion Date :||May 2005|
- Intubation rate
- time of recovery
- hospital length of stay
- mortality and improvement in gas exchange
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00446498
|Ospedale San Giovanni Bosco Medicina d'Urgenza|
|Torino, Italy, 10154|
|Principal Investigator:||Giovanni Ferrari, MD||Ospedale San Giovanni Bosco ASL4|
|Principal Investigator:||Giovanni Ferrari, MD||Ospedale San Giovanni Bosco ASL4 Torino Italy|