CPAP Versus NPPV in ACPE
To assess the intubation rate in patients affected by severe cardiogenic pulmonary edema treated with CPAP or NPPV.
|Study Design:||Allocation: Randomized
Endpoint Classification: Efficacy Study
Intervention Model: Parallel Assignment
Masking: Open Label
Primary Purpose: Treatment
|Official Title:||Continuous Positive Airway Pressure Versus Non-Invasive Positive Pressure Support Ventilation in Acute Cardiogenic Pulmonary Oedema: a Prospective Randomised Multicentre Trial.|
- Intubation rate
- time of recovery
- hospital length of stay
- mortality and improvement in gas exchange
|Study Start Date:||July 2002|
|Study Completion Date:||May 2005|
Background Although non-invasive ventilation has shown to be an effective treatment for acute cardiogenic pulmonary oedema (ACPO), literature still lacks of multi-centre randomised prospective studies that compares CPAP with NPPV.
Aim of the study was to assess efficacy and safety of CPAP and NPPV in patients with ACPO.
Methods 80 patients with ACPO were randomly assigned to receive CPAP or NPPV (40 for each group) through a face mask.
Inclusion criteria were: severe dyspnoea, respiratory rate > 30, PaO2/FiO2 < 200, muscle fatigue.
Main end-points were endotracheal intubation, length of ventilation, hospital length of stay and mortality.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00446498
|Ospedale San Giovanni Bosco Medicina d'Urgenza|
|Torino, Italy, 10154|
|Principal Investigator:||Giovanni Ferrari, MD||Ospedale San Giovanni Bosco ASL4|
|Principal Investigator:||Giovanni Ferrari, MD||Ospedale San Giovanni Bosco ASL4 Torino Italy|