Corneal Endothelial Cell Loss in Diabetes Type II During Cataract Surgery
The aim of the present study is to evaluate changes in the morphology and function of the corneal endothelium before and after cataract surgery in patients with diabetes type II. Also to explain if determination of HgbA1c in diabetics is a predictor for the changes in morphology and function.
|Study Design:||Observational Model: Case-Only
Time Perspective: Prospective
|Official Title:||Corneal Endothelial Cell Loss in Diabetes Type II During Cataract Surgery|
- corneal endothelial cell count (cells / mm2)
- percentage of hexagonal cells
- variation in cell size
- central corneal thickness
- visual acuity
- intraocular pressure
|Study Start Date:||January 2007|
|Estimated Study Completion Date:||June 2007|
|Estimated Primary Completion Date:||June 2007 (Final data collection date for primary outcome measure)|
Thirty patients with Diabetes type II and thirty non-diabetes patients scheduled to cataract surgery (phacoemulsification with intraocular lens implantation) were invited to participate in the study. Preoperatively, all patients had a full eye examination and 3 endothelial cell photos were taken.
Three months postoperatively the patients were called for a re-examination including 3 endothelial cell photos. The function of the cornea is dependent of the number and morphology of the endothelial cells, and even small traumas like cataract surgery may disrupt the cornea integrity leading to corneal haze and blur. Diabetics may be more vulnerable to corneal stress.
Please refer to this study by its ClinicalTrials.gov identifier: NCT00446277
|Department of Ophthalmology, Frederiksberg University Hospital|
|Frederiksberg, Copenhagen, Denmark, 2000|
|Principal Investigator:||Allan Storr-Paulsen, MD||Frederiksberg University Hospital|