Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation
Recruitment status was: Recruiting
The current knowledge of the pathophysiology of allergic contact dermatitis is based on the murine model. In this model, CD8+ T cells are effector cells, and CD4+ T cells regulate the response by limiting the expansion of CD8+ T cells. The goal of this study is to characterize the pathophysiology of contact dermatitis, with patients allergic to para-phenylenediamine (PPD).
We suppose that the CD8+ T cells are the effectors of the allergic contact dermatitis, although the regulator cells belong to the LT CD4+ population. We will test our hypothesis on blood samples, and cutaneous biopsies of patients allergic to PPD.
Allergic Contact Dermatitis
|Study Design:||Observational Model: Defined Population
Time Perspective: Longitudinal
Time Perspective: Prospective
|Official Title:||Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00445029
|Lyon, France, 69495|
|Principal Investigator:||Jean-François Nicolas, MD||Hospices Civils de Lyon|