Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation
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|ClinicalTrials.gov Identifier: NCT00445029|
Recruitment Status : Unknown
Verified October 2007 by Hospices Civils de Lyon.
Recruitment status was: Recruiting
First Posted : March 8, 2007
Last Update Posted : October 4, 2007
The current knowledge of the pathophysiology of allergic contact dermatitis is based on the murine model. In this model, CD8+ T cells are effector cells, and CD4+ T cells regulate the response by limiting the expansion of CD8+ T cells. The goal of this study is to characterize the pathophysiology of contact dermatitis, with patients allergic to para-phenylenediamine (PPD).
We suppose that the CD8+ T cells are the effectors of the allergic contact dermatitis, although the regulator cells belong to the LT CD4+ population. We will test our hypothesis on blood samples, and cutaneous biopsies of patients allergic to PPD.
|Condition or disease|
|Allergic Contact Dermatitis|
|Study Type :||Observational|
|Estimated Enrollment :||36 participants|
|Observational Model:||Defined Population|
|Official Title:||Pathophysiological Study of Allergic Contact Dermatitis to Para-Phenylenediamine (PPD). Analysis of Cellular and Molecular Targets in Skin Inflammation|
|Study Start Date :||March 2007|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00445029
|Contact: Marc Vocanson, PhD||33 4 78 86 firstname.lastname@example.org|
|Lyon, France, 69495|
|Principal Investigator:||Jean-François Nicolas, MD||Hospices Civils de Lyon|