A Study of Controlled-Release Carvedilol Compared to Immediate-Release Carvedilol in Patients With Primary Hypertension
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Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
A Phase II, Multi-center, Multiple-dose, Double-blind, Randomized, Crossover Study Comparing the Pharmacodynamic Effects of a Once-daily Controlled-Release Carvedilol (CRC; Egalet® Formulation) and an Immediate-Release Carvedilol (IRC) Formulation in Patients With Primary Hypertension
Study Start Date :
Actual Primary Completion Date :
Actual Study Completion Date :
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Ages Eligible for Study:
18 Years and older (Adult, Older Adult)
Sexes Eligible for Study:
Accepts Healthy Volunteers:
Have a diagnosis of mild or moderate primary hypertension
Be able to tolerate a 2 week washout phase followed by a 2 week Placebo run- in phase
Be minimum 18 years of age
Be intolerant to alfa- or beta-blockers
Have secondary causes of hypertension
Be taking more than two antihypertensive medications