Glucose Control by eMPC Algorithm in Peri- and Postoperative Period in Cardiac Surgery Patients
|ClinicalTrials.gov Identifier: NCT00444171|
Recruitment Status : Completed
First Posted : March 7, 2007
Last Update Posted : March 7, 2007
|Condition or disease||Intervention/treatment|
|Cardiac Surgery Patients Blood Glucose||Procedure: insulin infusion rate controled by computer algorithm Procedure: insulin infusion rate guided by in-house glucose management protocol|
Context. Increased blood glucose levels frequently occur in critically ill patients and its normalization by intensive insulin treatment markedly improves clinical outcome.
Objective and Design: Randomized controlled trial to compare blood glucose control by the model predictive control algorithm with variable sampling rate (eMPC) with routine glucose management protocol (RMP) in peri- and postoperative period in cardiac surgery patients.
Setting: Department of Cardiac Surgery, University Hospital. Patients. 60 cardiac surgery patients. Interventions. Elective cardiac surgery and treatment with continuous insulin infusion to maintain euglycemia (target range 4.4 – 6.1 mmol/l). 30 patients were randomized for eMPC and 30 for RMP treatment. Blood glucose was measured in 1-4 hour intervals depending on request of each algorithm during surgery and post-operation period for 24 hours.
Main Outcome Measures. Mean blood glucose, percentage of time in target range. Results. Mean blood glucose was 6.15 ± 1.11 mmol/l in eMPC vs. 7.21 ± 1.08 mmol/l in RMP group (p<0.05); percentage of time in target range was 60.4 ± 22.8% for eMPC vs. 27.5 ± 16.2% for RMP group (p<0.05). No severe hypoglycemia (blood glucose bellow 2.9 mmol/l) was observed during the study. Average insulin infusion rate was 4.67 ± 3.34 in eMPC vs. 2.57 ± 1.66 IU/h in RMP (p<0.05), average sampling interval was 1.46 ± 0.31 vs. 2.10 ± 0.22 hours (p<0.05).
Conclusions. eMPC algorithm was more effective and comparably safe as compared to RMP in maintaining euglycemia in cardiac surgery patients.
|Study Type :||Interventional (Clinical Trial)|
|Estimated Enrollment :||60 participants|
|Intervention Model:||Parallel Assignment|
|Masking:||None (Open Label)|
|Official Title:||Randomized Controlled Trial to Evaluate Blood Glucose Control by the Model Predictive Control Algorithm With Variable Sampling Rate (eMPC) vs. Routine Glucose Management Protocol in Peri- and Postoperative Period in Cardiac Surgery Patients|
|Study Start Date :||September 2006|
|Estimated Study Completion Date :||February 2007|
- Mean blood glucose
- percentage of time in target range
- Number of hypoglycaemic episodes
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00444171
|General University Hospital|
|Praha, Czech Republic, 12808|
|Principal Investigator:||Stepan Svacina, MD, DSc||Charles University Prague|