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Genetic Analysis of Thyrotoxic Periodic Paralysis

This study has been completed.
ClinicalTrials.gov Identifier:
First Posted: March 6, 2007
Last Update Posted: March 6, 2007
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by:
Ramathibodi Hospital
Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Thyrotoxic Periodic Paralysis

Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Time Perspective: Retrospective
Official Title: Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

Resource links provided by NLM:

Further study details as provided by Ramathibodi Hospital:

Estimated Enrollment: 80
Study Start Date: January 2004
Estimated Study Completion Date: December 2005
Detailed Description:
This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.

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Ages Eligible for Study:   15 Years and older   (Child, Adult, Senior)
Sexes Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:


  • Hyperthyroid patients from any causes
  • Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)
  • Episodic paralysis

Exclusion Criteria:

  • Hypokalemia from GI or renal loss
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00443833

Sponsors and Collaborators
Ramathibodi Hospital
Principal Investigator: Wallaya Jongjaroenprasert, MD Endocrinology Unit, Ramathibodi Hospital, Mahidol University
  More Information

ClinicalTrials.gov Identifier: NCT00443833     History of Changes
Other Study ID Numbers: 11-46-21
First Submitted: March 5, 2007
First Posted: March 6, 2007
Last Update Posted: March 6, 2007
Last Verified: March 2007

Keywords provided by Ramathibodi Hospital:
genetic association study
periodic paralysis
whole genome scan

Additional relevant MeSH terms:
Neurologic Manifestations
Nervous System Diseases
Signs and Symptoms