Genetic Analysis of Thyrotoxic Periodic Paralysis

This study has been completed.
Information provided by:
Ramathibodi Hospital Identifier:
First received: March 5, 2007
Last updated: NA
Last verified: March 2007
History: No changes posted

Thyrotoxic periodic paralysis (TPP) is characterized by episodes of reversible hypokalemia and weakness in thyrotoxic patients. It is commonly found in males of Asian descent and is also seen in individuals having Native American or Hispanic ancestry. Therefore genetic etiology has been hypothesized. This study, we aim to find the susceptibility genes that associate with TPP. Both candidate genes approach and genome wide association study have been conducted.

Thyrotoxic Periodic Paralysis

Study Type: Observational
Study Design: Observational Model: Case Control
Primary Purpose: Screening
Time Perspective: Cross-Sectional
Official Title: Genetic Analysis of Thai Patients With Thyrotoxic Periodic Paralysis

Resource links provided by NLM:

Further study details as provided by Ramathibodi Hospital:

Estimated Enrollment: 80
Study Start Date: January 2004
Estimated Study Completion Date: December 2005
Detailed Description:

This study is a genetic association study. It included 50 cases of TPP patients and 80 cases of male, hyperthyroid patients who didn't have hypokalemia as a well characterized controls. After informed consent were obtained, genomic DNA from leukocyte were extracted. Pooled DNA were constructed and whole genome scan using 10K GeneChip microarray were genotyped on pooled genomic DNA.


Ages Eligible for Study:   15 Years and older
Genders Eligible for Study:   Male
Accepts Healthy Volunteers:   No

Inclusion Criteria:


  • Hyperthyroid patients from any causes
  • Evidence of hypokalemia (k<3.5 mg/dl)from intracellular shift (Urine K<15 mg/dl, TTKG<2)
  • Episodic paralysis

Exclusion Criteria:

  • Hypokalemia from GI or renal loss
  Contacts and Locations
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Please refer to this study by its identifier: NCT00443833

Sponsors and Collaborators
Ramathibodi Hospital
Principal Investigator: Wallaya Jongjaroenprasert, MD Endocrinology Unit, Ramathibodi Hospital, Mahidol University
  More Information

No publications provided Identifier: NCT00443833     History of Changes
Other Study ID Numbers: 11-46-21
Study First Received: March 5, 2007
Last Updated: March 5, 2007
Health Authority: Thailand: Ethical Committee

Keywords provided by Ramathibodi Hospital:
genetic association study
periodic paralysis
whole genome scan

Additional relevant MeSH terms:
Nervous System Diseases
Neurologic Manifestations
Signs and Symptoms processed this record on October 02, 2015