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Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women

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ClinicalTrials.gov Identifier: NCT00443716
Recruitment Status : Completed
First Posted : March 6, 2007
Last Update Posted : January 15, 2010
Sponsor:
Information provided by:
Mayo Clinic

Brief Summary:
To evaluate the effect of estrogen treatment on adipocytic and osteoblastic parameters by histomorphometrically measuring adipocyte volume (AV/TV) and adipocyte numbers in goldner's stained iliac crest bone biopsy specimens collected from subjects recruited in the study (IRB number 21B85). The adipocytic parameters will be then correlated with osteoblastic parameters obtained previously during the course of the initai study involving the effect of transdermal estrogen on bone turnover in postmenopausal osteoporotic women.

Condition or disease Intervention/treatment
Osteoporosis Postmenopausal Drug: estrogen

Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 60 participants
Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Determination of Adipocyte Parameters in Iliac Crest Biopsies From Post Menopausal Women
Study Start Date : April 1985
Primary Completion Date : April 1989
Study Completion Date : April 1989

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Biopsy
U.S. FDA Resources




Primary Outcome Measures :
  1. efficacy of estraderm treatment on osteoporotic women


Information from the National Library of Medicine

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Ages Eligible for Study:   30 Years and older   (Adult, Senior)
Sexes Eligible for Study:   Female
Accepts Healthy Volunteers:   Yes
Criteria
Post-menopausal osteoporotic women

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00443716


Locations
United States, Minnesota
Mayo Clinic
Rochester, Minnesota, United States, 55905
Sponsors and Collaborators
Mayo Clinic
Investigators
Principal Investigator: B. Lawrence Riggs, M.D. Mayo Clinic

ClinicalTrials.gov Identifier: NCT00443716     History of Changes
Other Study ID Numbers: 05-004111
21b85
First Posted: March 6, 2007    Key Record Dates
Last Update Posted: January 15, 2010
Last Verified: January 2010

Additional relevant MeSH terms:
Osteoporosis
Bone Diseases, Metabolic
Bone Diseases
Musculoskeletal Diseases
Metabolic Diseases
Estrogens
Hormones
Hormones, Hormone Substitutes, and Hormone Antagonists
Physiological Effects of Drugs