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Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

This study is currently recruiting participants. (see Contacts and Locations)
Verified September 2016 by Odense University Hospital
Sponsor:
Information provided by (Responsible Party):
Evy Paulsen, Odense University Hospital
ClinicalTrials.gov Identifier:
NCT00442091
First received: February 28, 2007
Last updated: September 26, 2016
Last verified: September 2016
  Purpose
Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Condition Intervention
Vesicular Palmoplantar Eczema
Pompholyx
Drug: dandelion juice

Study Type: Interventional
Study Design: Endpoint Classification: Efficacy Study
Intervention Model: Single Group Assignment
Masking: Open Label
Primary Purpose: Treatment
Official Title: Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

Resource links provided by NLM:


Further study details as provided by Odense University Hospital:

Primary Outcome Measures:
  • Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score. [ Time Frame: 3-4 weeks ] [ Designated as safety issue: No ]

Secondary Outcome Measures:
  • Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale). [ Time Frame: 3-4 weeks ] [ Designated as safety issue: No ]

Estimated Enrollment: 4
Study Start Date: December 2010
Estimated Study Completion Date: December 2019
Estimated Primary Completion Date: December 2016 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
10 ml of dandelion juice twice daily Drug: dandelion juice
10 ml bid for 20-30 days

Detailed Description:

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients.

The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.

  Eligibility

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Genders Eligible for Study:   Both
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests.

Exclusion Criteria:

  • Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months.
  • Pregnancy, lactation.
  • Compositae contact allergy.
  • Liver or gall bladder disease.
  • Abnormal renal or hepatic blood tests.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00442091

Contacts
Contact: Evy Paulsen, Dr. +6541 2705 evy.paulsen@regionsyddanmark.dk

Locations
Denmark
Department of Dermatology, Odense University Hospital Recruiting
Odense, Denmark, DK-5000
Contact: Evy Paulsen, Dr.    +45 6541 2705    evy.paulsen@regionsyddanmark.dk   
Contact: Klaus E Andersen, Professor    +45 6541 2700    klaus.ejner.andersen@regionsyddanmark.dk   
Principal Investigator: Evy Paulsen, Dr.         
Sponsors and Collaborators
Odense University Hospital
Investigators
Principal Investigator: Evy Paulsen, Dr. Department of Dermatology, Odense University Hospital, DK-5000 Odense C
  More Information

Responsible Party: Evy Paulsen, Consultant dermatologist, Ph.D., Odense University Hospital
ClinicalTrials.gov Identifier: NCT00442091     History of Changes
Other Study ID Numbers: 20070010 
Study First Received: February 28, 2007
Last Updated: September 26, 2016
Health Authority: Denmark: Ethics Committee
Individual Participant Data  
Plan to Share IPD: No

Keywords provided by Odense University Hospital:
Dandelion
herbal remedy
hand eczema
Compositae

Additional relevant MeSH terms:
Eczema
Eczema, Dyshidrotic
Dermatitis
Skin Diseases
Skin Diseases, Eczematous
Skin Diseases, Vesiculobullous

ClinicalTrials.gov processed this record on December 09, 2016