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Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema

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ClinicalTrials.gov Identifier: NCT00442091
Recruitment Status : Recruiting
First Posted : March 1, 2007
Last Update Posted : September 20, 2017
Sponsor:
Information provided by (Responsible Party):
Evy Paulsen, Odense University Hospital

Brief Summary:
Dandelion juice has been used in herbal medicine for at least 1000 years. Vesicular hand eczema is a rare, but difficult to treat, type of hand eczema. One case report has shown that ingestion of dandelion juice could induce a beneficial effect on this type of eczema. The purpose of this study is to test whether this effect can be retrieved in other patients.

Condition or disease Intervention/treatment Phase
Vesicular Palmoplantar Eczema Pompholyx Drug: dandelion juice Not Applicable

Detailed Description:

Dandelion juice has been used in herbal medicine for at least 1000 years. One case report has shown a beneficial effect of this herbal remedy on dyshidrotic hand eczema, and the purpose of this pilot study is to test whether this effect can be retrieved in other patients.

The patients are recruited from our out-patient clinic. Only patients with negative patch tests to Compositae are offered treatment with dandelion juice for 20-30 days.


Study Type : Interventional  (Clinical Trial)
Estimated Enrollment : 4 participants
Intervention Model: Single Group Assignment
Masking: None (Open Label)
Primary Purpose: Treatment
Official Title: Dandelion Juice in the Treatment of Dyshidrotic Hand Eczema
Study Start Date : December 2010
Estimated Primary Completion Date : December 2019
Estimated Study Completion Date : December 2019

Resource links provided by the National Library of Medicine

MedlinePlus related topics: Eczema

Arm Intervention/treatment
10 ml of dandelion juice twice daily Drug: dandelion juice
10 ml bid for 20-30 days




Primary Outcome Measures :
  1. Improvement in dyshidrotic hand eczema in the study period assessed by HECSI score. [ Time Frame: 3-4 weeks ]

Secondary Outcome Measures :
  1. Improvement in dyshidrotic eczema in the study period assessed by the patient (Visual Analog Scale). [ Time Frame: 3-4 weeks ]


Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years and older   (Adult, Older Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Criteria

Inclusion Criteria:

  • Adult patients with dyshidrotic eczema for at least 1 year and negative patch test reactions to Compositae (tested within the last 3 years) and normal renal and hepatic blood tests.

Exclusion Criteria:

  • Treatment with systemic steroids or other immunosuppressive/-modulating drugs, including UV therapy, within the last 3 months.
  • Pregnancy, lactation.
  • Compositae contact allergy.
  • Liver or gall bladder disease.
  • Abnormal renal or hepatic blood tests.

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00442091


Contacts
Contact: Evy Paulsen, Dr. +6541 2705 evy.paulsen@regionsyddanmark.dk

Locations
Denmark
Department of Dermatology, Odense University Hospital Recruiting
Odense, Denmark, DK-5000
Contact: Evy Paulsen, Dr.    +45 6541 2705    evy.paulsen@regionsyddanmark.dk   
Contact: Klaus E Andersen, Professor    +45 6541 2700    klaus.ejner.andersen@regionsyddanmark.dk   
Principal Investigator: Evy Paulsen, Dr.         
Sponsors and Collaborators
Odense University Hospital
Investigators
Principal Investigator: Evy Paulsen, Dr. Department of Dermatology, Odense University Hospital, DK-5000 Odense C

Responsible Party: Evy Paulsen, Consultant dermatologist, Ph.D., Odense University Hospital
ClinicalTrials.gov Identifier: NCT00442091     History of Changes
Other Study ID Numbers: 20070010
First Posted: March 1, 2007    Key Record Dates
Last Update Posted: September 20, 2017
Last Verified: September 2017
Individual Participant Data (IPD) Sharing Statement:
Plan to Share IPD: No

Keywords provided by Evy Paulsen, Odense University Hospital:
Dandelion
herbal remedy
hand eczema
Compositae

Additional relevant MeSH terms:
Eczema
Eczema, Dyshidrotic
Dermatitis
Skin Diseases
Skin Diseases, Eczematous
Skin Diseases, Vesiculobullous