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Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

The recruitment status of this study is unknown. The completion date has passed and the status has not been verified in more than two years.
Verified February 2009 by Radboud University.
Recruitment status was:  Recruiting
Information provided by:
Radboud University Identifier:
First received: February 28, 2007
Last updated: February 5, 2009
Last verified: February 2009
Survivors of a cardiac arrest frequently develop severe postanoxic encephalopathy. Derangements in cerebral blood after return of spontaneous circulation play an important role in the pathogenesis of postanoxic encephalopathy. In the present study we examine the effect of mild therapeutic hypothermia on cerebral blood flow and carbondioxide reactivity in patients after cardiac arrest.

Cardiac Arrest
Post-Anoxic Encephalopathy

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Cerebral Bloodflow and Carbondioxide Reactivity During Mild Therapeutic Hypothermia in Patients After Cardiac Arrest

Resource links provided by NLM:

Further study details as provided by Radboud University:

Estimated Enrollment: 10
Study Start Date: September 2006

Ages Eligible for Study:   18 Years to 95 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
Patients after cardiac arrest, comatose and treated with therapeutic hypothermia

Inclusion Criteria:

  • adult patients
  • GCS after return of circulation < 7
  • Induced mild hypothermia for 24 hours
  • primary rhythm ventricular fibrillation

Exclusion Criteria:

  • Thrombolysis
  • Cardiogenic shock with expected survival < 24 hrs
  • Pregnancy
  • No informed consent
  Contacts and Locations
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Please refer to this study by its identifier: NCT00441753

Contact: Cornelia Hoedemaekers, MD PhD

Radboud University Nijmegen Medical Centre Recruiting
Nijmegen, Netherlands, 6500 HB
Contact: Cornelia Hoedemaekers, MD PhD   
Sub-Investigator: Koen Simons, MD         
Sponsors and Collaborators
Radboud University
Principal Investigator: Cornelia Hoedemaekers, MD PhD Radboud University
Study Director: Johannes van der Hoeven, MD PhD Radboud University
  More Information

Responsible Party: Radboud UNiversity Nijmegen Medical Centre Identifier: NCT00441753     History of Changes
Other Study ID Numbers: KSCH0601
Study First Received: February 28, 2007
Last Updated: February 5, 2009

Additional relevant MeSH terms:
Heart Arrest
Brain Diseases
Hypoxia, Brain
Heart Diseases
Cardiovascular Diseases
Body Temperature Changes
Signs and Symptoms
Central Nervous System Diseases
Nervous System Diseases processed this record on May 23, 2017