Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise
|ClinicalTrials.gov Identifier: NCT00441714|
Recruitment Status : Withdrawn (new insights have let us to expect marginal annexin targeting with a 10 minutes delay between reperfusion and administration of Annexin A5)
First Posted : March 1, 2007
Last Update Posted : November 10, 2015
To adjust our forearm model for ischemia reperfusion injury, in order to used it for assessment of ischemia reperfusion damage in elderly and patients.
To test the effect of ischemic postconditioning on ischemia reperfusion injury in healthy volunteers, using Annexin binding after repetitive handgripping.
|Condition or disease||Intervention/treatment|
|Cardiovascular Disease Ischemia-reperfusion Injury Postconditioning||Procedure: repetitive short ischemia and reperfusion of non dominant fore arm after 10 minute ischemic exercise|
|Study Type :||Interventional (Clinical Trial)|
|Actual Enrollment :||0 participants|
|Intervention Model:||Crossover Assignment|
|Masking:||None (Open Label)|
|Official Title:||Effect of Ischemic Postconditioning on Targeting of Annexin A5 After Forearm Exercise|
|Study Start Date :||October 2007|
|Estimated Study Completion Date :||December 2007|
- Annexin A 5 targeting in the non dominant thenar muscle after (ischemic exercise), as a indicator for ischemia reperfusion injury.
- Workload during (ischemic) exercise.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00441714
|Radboud University Nijmegen Medical Centre|
|Nijmegen, Netherlands, 6500HB|
|Principal Investigator:||Gerard Rongen, MD PhD||RUMCN|