Anesthesia in Flexible Bronchoscopy for Lung Cancer Diagnostic

This study has been completed.
Information provided by:
Hospital Pompeia Identifier:
First received: February 26, 2007
Last updated: NA
Last verified: February 2007
History: No changes posted
The objective of the study was to establish which anesthetic procedure used during flexible bronchoscopy has the lowest index of complications.

Condition Intervention Phase
Lung Cancer
Drug: propofol
Drug: midazolam
Drug: alfentanil
Drug: lidocaine
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Factorial Assignment
Masking: Single Blind
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Hospital Pompeia:

Detailed Description:
This prospective randomized study analyzed 80 patients that underwent flexible bronchoscopy. Patients were randomly assigned to four groups of 20 patients each according to the anesthetic combination used: 200 mg topical lidocaine (LID group); 200 mg topical lidocaine and 2 mg/kg propofol (PPF group); 200 mg topical lidocaine and 20 mcg/kg alfentanil (ALF group); or 200 mg topical lidocaine and 0.05 mg/kg midazolam (MID group). Scores were assigned to patients according to the different variables observed during the endoscopic procedure; the lower the score, the lower the complication index.

Ages Eligible for Study:   18 Years and older
Genders Eligible for Study:   Both

Inclusion Criteria:

  • The patients included in this study were referred to FBC for the investigation of bronchial carcinoma (diagnostic procedure).
  • Patients included in the study were classified as ASA I, II and II according to the anesthetic risk classification of the American Society of Anesthesiologists (ASA).

Exclusion Criteria:

  • ASA IV classification of anesthesiology risk
  • procedure that lasted longer than 15 minutes
  • indication of therapeutic bronchoscopy
  • cardiac arrhythmia and / or hypoxemia detected at admission.
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Please refer to this study by its identifier: NCT00440960

General Hospital of Universidade de Caxias do Sul
Caxias do Sul, RS, Brazil, 95070-560
Hospital Medianeira
Caxias do Sul, RS, Brazil, 95040-000
Hospital Pompeia
Caxias do Sul, RS, Brazil, 95010-005
Sponsors and Collaborators
Hospital Pompeia
Principal Investigator: Andre GS Leite, PhD Brazilian Society of Thoracic Surgery
  More Information

Publications: Identifier: NCT00440960     History of Changes
Other Study ID Numbers: 0002.0.297.000-06
Study First Received: February 26, 2007
Last Updated: February 26, 2007
Health Authority: Brazil: Ministry of Health

Keywords provided by Hospital Pompeia:

Additional relevant MeSH terms:
Adjuvants, Anesthesia
Analgesics, Opioid
Anesthetics, General
Anesthetics, Intravenous
Anti-Anxiety Agents
Central Nervous System Agents
Central Nervous System Depressants
GABA Agents
GABA Modulators
Hypnotics and Sedatives
Molecular Mechanisms of Pharmacological Action
Neurotransmitter Agents
Peripheral Nervous System Agents
Pharmacologic Actions
Physiological Effects of Drugs
Psychotropic Drugs
Sensory System Agents
Therapeutic Uses
Tranquilizing Agents processed this record on November 25, 2015