Changes of Transforming Growth Factor b1 and Procollagen III in Patients With Acute Respiratory Distress Syndrome
Transforming Growth Factor-b1 (TGF-b1) is involved in the development of acute lung injury and in the fibroproliferation during acute respiratory distress syndrome (ARDS). Procollagen III Peptide (PIIINP) is a validated marker of fibroproliferation. PIIINP is associated with death in ARDS patients. The simultaneous changes of TGF-b1 and PIIINP were never studied in patients with ARDS. The relationships between TGF-b1 and the outcome of ARDS are unknown.
The aim of the study is to analyse the changes of TGF-b1 and PIIINP during ARDS and to show the relationships between TGF-b1 - PIIINP and the outcomes of ARDS.
|Acute Respiratory Distress Syndrome|
|Study Design:||Observational Model: Cohort
Time Perspective: Prospective
|Official Title:||Changes of Transforming Growth Factor b1 and Procollagen III in Patients With Acute Respiratory Distress Syndrome|
Please refer to this study by its ClinicalTrials.gov identifier: NCT00440882
|Hopital Sainte Marguerite|
|Marseille, France, 13009|
|Principal Investigator:||Jean-Marie FOREL, MD||AP-HM|