Changes of Transforming Growth Factor b1 and Procollagen III in Patients With Acute Respiratory Distress Syndrome
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|ClinicalTrials.gov Identifier: NCT00440882|
Recruitment Status : Completed
First Posted : February 27, 2007
Last Update Posted : October 9, 2008
Transforming Growth Factor-b1 (TGF-b1) is involved in the development of acute lung injury and in the fibroproliferation during acute respiratory distress syndrome (ARDS). Procollagen III Peptide (PIIINP) is a validated marker of fibroproliferation. PIIINP is associated with death in ARDS patients. The simultaneous changes of TGF-b1 and PIIINP were never studied in patients with ARDS. The relationships between TGF-b1 and the outcome of ARDS are unknown.
The aim of the study is to analyse the changes of TGF-b1 and PIIINP during ARDS and to show the relationships between TGF-b1 - PIIINP and the outcomes of ARDS.
|Condition or disease|
|Acute Respiratory Distress Syndrome|
|Study Type :||Observational|
|Estimated Enrollment :||80 participants|
|Official Title:||Changes of Transforming Growth Factor b1 and Procollagen III in Patients With Acute Respiratory Distress Syndrome|
|Study Start Date :||September 2004|
To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00440882
|Hopital Sainte Marguerite|
|Marseille, France, 13009|
|Principal Investigator:||Jean-Marie FOREL, MD||AP-HM|