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Expanded Access Protocol (EAP) to Provide Bortezomib to Patients With Multiple Myeloma Who Have Received at Least 2 Previous Lines of Therapy and Are Refractory to or Have Relapsed After Their Last Therapy for Multiple Myeloma

This study has been completed.
Information provided by:
Janssen-Cilag International NV Identifier:
First received: February 26, 2007
Last updated: April 15, 2013
Last verified: April 2013
The purpose of this study is to provide bortezomib to patients with multiple myeloma who have received at least 2 previous lines of therapy and are refractory or have relapse after their last treatment. Additional objectives of this study are assess the safety and tolerability of bortezomib and follow the levels of paraprotein in patients receiving bortezomib as a way to followup disease burden

Condition Intervention
Multiple Myeloma
Drug: Bortezomib, tradename Velcade

Study Type: Observational
Study Design: Time Perspective: Prospective
Official Title: International Single-Arm Protocol to Provide Expanded Access to Bortezomib for Patients With Multiple Myeloma Who Have Received at Least 2 Previous Lines of Therapy and Are Refractory to or Have Relapsed After Their Last Therapy for Multiple Myeloma

Resource links provided by NLM:

Further study details as provided by Janssen-Cilag International NV:

Enrollment: 641
Study Start Date: January 2004
Study Completion Date: October 2006
Detailed Description:
Multiple myeloma is uniformly fatal. Responses achieved after multiple lines of therapy are normally of short duration. Therefore, all patients with multiple myeloma will eventually relapse, having become refractory to therapy and subsequently will die of their cancer. The rationale of this study is that bortezomib as a novel agent may allow additional periods of response due to its different mechanisms of action. This is an open-label, single-arm, multicenter, non-comparative study to provide expanded access to bortezomib to patients with multiple myeloma that have received at least two previous lines of therapy and are refractory to or have relapsed after their last treatment. Patients will receive treatment with bortezomib 1.3 mg/m2 on day 1, 4, 8 and 11 of a 3-week cycle. No treatment will be administered on the last 10 days of each cycle. Treatment may be repeated for up to 8 cycles with possible extension if patient is still responding at the end of the 8 cycle period. Bortezomib 1.3 mg/m2 will be administered as an IV bolus

Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Patients with previous diagnosis of multiple myeloma based on standard criteria
  • patient has received at least 2 previous lines of therapy for multiple myeloma and, currently requires therapy because of relapsed or progressive disease
  • If female, the patient is either postmenopausal or surgically sterilized or willing to use an acceptable method of birth control (i.e., a hormonal contraceptive, intrauterine device, diaphragm with spermicide, or condom with spermicide, or abstinence) from Screening through the Final Visit
  • If male, the patient agrees to use an acceptable barrier method for contraception from Screening through the Final Visit
  • patient has a Karnofsky performance status >= 60
  • patient meets defined pretreatment laboratory criteria

Exclusion Criteria:

  • If patient received bortezomib in a previous clinical trial, the patient's best response to bortezomib was progressive disease
  • Patient received nitrosoureas within 6 weeks or any other chemotherapy within 3 weeks before enrollment, corticosteroids (>10 mg/day prednisone or equivalent) within 3 weeks before enrollment, immunotherapy or antibody therapy within 4 weeks before enrollment
  • Patient has peripheral neuropathy of Grade 2 or greater intensity, as defined by the NCI CTC
  • Patient had a myocardial infarction within 6 months of enrollment or has New York Heart Association (NYHA) Class III or IV heart failure, uncontrolled angina, severe uncontrolled ventricular arrhythmias, or electrocardiographic evidence of acute ischemia or active conduction system abnormalities
  • Patient has cardiac amyloidosis
  Contacts and Locations
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Please refer to this study by its identifier: NCT00440635

Sponsors and Collaborators
Janssen-Cilag International NV
Study Director: Janssen-Cilag International NV Clinical Trial Janssen-Cilag International NV
  More Information

Publications automatically indexed to this study by Identifier (NCT Number): Identifier: NCT00440635     History of Changes
Other Study ID Numbers: CR002185
Study First Received: February 26, 2007
Last Updated: April 15, 2013

Keywords provided by Janssen-Cilag International NV:
Multiple myeloma
bortezomib, Hematology

Additional relevant MeSH terms:
Multiple Myeloma
Neoplasms, Plasma Cell
Neoplasms by Histologic Type
Hemostatic Disorders
Vascular Diseases
Cardiovascular Diseases
Blood Protein Disorders
Hematologic Diseases
Hemorrhagic Disorders
Lymphoproliferative Disorders
Immunoproliferative Disorders
Immune System Diseases
Antineoplastic Agents processed this record on May 22, 2017