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Brimonidine 0.1% Versus Brinzolamide 1% as Adjunctive Therapy to Latanoprost 0.005%

This study has been completed.
Information provided by:
Allergan Identifier:
First received: February 22, 2007
Last updated: December 26, 2007
Last verified: December 2007
Patients with glaucoma or ocular hypertension currently being treated with latanoprost 0.005%, and in need of additional IOP lowering will be randomized to receive either brimonidine 0.1% or brinzolamide 1% three-times daily as adjunctive therapy to latanoprost 0.005%

Condition Intervention Phase
Ocular Hypertension
Drug: latanoprost 0.005% eye drops and brimonidine 0.1% eye drops
Drug: latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops
Phase 4

Study Type: Interventional
Study Design: Allocation: Randomized
Intervention Model: Parallel Assignment
Masking: Single Blind (Investigator)
Primary Purpose: Treatment

Resource links provided by NLM:

Further study details as provided by Allergan:

Primary Outcome Measures:
  • IOP [ Time Frame: Month 3 ]

Secondary Outcome Measures:
  • Tolerability [ Time Frame: Month 3 ]

Enrollment: 40
Study Start Date: July 2006
Study Completion Date: March 2007
Primary Completion Date: March 2007 (Final data collection date for primary outcome measure)
Arms Assigned Interventions
Experimental: 1 Drug: latanoprost 0.005% eye drops and brimonidine 0.1% eye drops
latanoprost 0.005%, 1 drop nightly for 3 months and brimonidine 0.1% three-times daily for 3 months
Other Names:
  • Xalatan®
  • Alphagan® P
Active Comparator: 2 Drug: latanoprost 0.005% eye drops and brinzolamide 1.0% eye drops
latanoprost 0.005% 1 drop nightly for 3 months AND brinzolamide 1.0% 1% three-times daily for 3 months
Other Names:
  • Xalatan®
  • Azopt®


Ages Eligible for Study:   18 Years and older   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No

Inclusion Criteria:

  • Glaucoma or ocular hypertension in both eyes
  • Currently being treated with latanoprost 0.005% QD
  • IOP greater than or equal to 18mm Hg on latanoprost 0.005%
  • Best-corrected VA of 20/200 or better in each eye
  • Visual field within 6 months of study entry

Exclusion Criteria:

  • Secondary glaucoma
  • Active intraocular inflammation or macular edema
  • Intraocular surgery or laser surgery within the past 3 months
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Please refer to this study by its identifier: NCT00440141

United States, Georgia
Atlanta, Georgia, United States
Sponsors and Collaborators
Study Director: Medical Affairs Allergan
  More Information

Publications automatically indexed to this study by Identifier (NCT Number):
Responsible Party: Therapeutic Area Head, Allergan, Inc. Identifier: NCT00440141     History of Changes
Other Study ID Numbers: MA-AP01
Study First Received: February 22, 2007
Last Updated: December 26, 2007

Additional relevant MeSH terms:
Ocular Hypertension
Eye Diseases
Brimonidine Tartrate
Ophthalmic Solutions
Antihypertensive Agents
Adrenergic alpha-2 Receptor Agonists
Adrenergic alpha-Agonists
Adrenergic Agonists
Adrenergic Agents
Neurotransmitter Agents
Molecular Mechanisms of Pharmacological Action
Physiological Effects of Drugs
Carbonic Anhydrase Inhibitors
Enzyme Inhibitors
Pharmaceutical Solutions
Autonomic Agents
Peripheral Nervous System Agents
Nasal Decongestants
Vasoconstrictor Agents
Respiratory System Agents processed this record on May 22, 2017