Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance
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ClinicalTrials.gov Identifier: NCT00438438 |
Recruitment Status
:
Completed
First Posted
: February 22, 2007
Last Update Posted
: September 2, 2011
|
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Condition or disease | Intervention/treatment | Phase |
---|---|---|
Healthy | Behavioral: forced desynchrony protocol with sleep restriction | Not Applicable |
Study Type : | Interventional (Clinical Trial) |
Estimated Enrollment : | 9 participants |
Allocation: | Randomized |
Intervention Model: | Crossover Assignment |
Masking: | None (Open Label) |
Primary Purpose: | Health Services Research |
Official Title: | "Interaction of Chronic Sleep Restriction and Circadian Misalignment on Sleep and Neuro-cognitive Performance" |
Study Start Date : | April 2006 |
Actual Primary Completion Date : | November 2008 |
Actual Study Completion Date : | November 2008 |

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Behavioral: forced desynchrony protocol with sleep restriction
- Sleep Stage [ Time Frame: 38 days ]
- Circadian Phase (melatonin rhythm) [ Time Frame: 38 days ]
- Psychomotor Vigilance Task [ Time Frame: 38 days ]
- Digit Symbol Substitution Task [ Time Frame: 38 days ]
- Addition Task [ Time Frame: 38 days ]
- Karolinska Sleepiness Scale [ Time Frame: 38 days ]
- Karolinska Drowsiness Test [ Time Frame: 38 days ]
- Mood Scales [ Time Frame: 38 days ]
- Flanker Task [ Time Frame: 38 days ]
- Multiple Object Tracking [ Time Frame: 38 days ]

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Ages Eligible for Study: | 18 Years to 35 Years (Adult) |
Sexes Eligible for Study: | All |
Accepts Healthy Volunteers: | Yes |
Inclusion Criteria:
- Age 18-35 years old
- Medically healthy
Exclusion Criteria:
- Sleep disorder
- Psychiatric illness
- Chronic medical condition
- No prescription or Non-prescription medications

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00438438
United States, Massachusetts | |
Brigham and Woman's Hospital | |
Boston, Massachusetts, United States, 02115 |
Principal Investigator: | Elizabeth B Klerman, M.D., Ph.D. | Brigham and Woman's Hospital | |
Principal Investigator: | Charles A Czeisler, Ph.D., M.D. | Brigham and Woman's Hospital |
Responsible Party: | Elizabeth B. Klerman, Associate Professor, Associate Physician, Brigham and Women's Hospital |
ClinicalTrials.gov Identifier: | NCT00438438 History of Changes |
Other Study ID Numbers: |
2200-100792 |
First Posted: | February 22, 2007 Key Record Dates |
Last Update Posted: | September 2, 2011 |
Last Verified: | August 2011 |
Keywords provided by Elizabeth B. Klerman, Brigham and Women's Hospital:
forced desynchrony circadian rhythms sleep restriction sleep homeostasis neurobehavioral performance |