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Vasoactive Hormones and Oxygen Saturation During Apneic Events in Patients With Obstructive Sleep Apnea

This study has suspended participant recruitment.
(It was not possible to recruit enough patients with obstructive sleep apnea.)
Information provided by:
Regional Hospital Holstebro Identifier:
First received: February 20, 2007
Last updated: April 17, 2008
Last verified: April 2008

The mechanisms involved in development and maintenance of hypertension in obstructive sleep apnea are not clarified.

We hypothesize that patients with obstructive sleep apnea have an abnormal level of some vasoactive hormones during apneic events during sleep.

Condition Phase
Obstructive Sleep Apnea
Phase 4

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:

Further study details as provided by Regional Hospital Holstebro:

Estimated Enrollment: 40
Study Start Date: October 2006

Ages Eligible for Study:   20 Years to 65 Years   (Adult)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   Yes
Sampling Method:   Probability Sample
Study Population
Adults, males and females,age 30 -65

Patients with Obstructive sleep apnea

Inclusion Criteria:

  • Severe obstructive sleep apnea (apnea-hypopnea index > 30)

Exclusion Criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes

Healthy Controls

Inclusion Criteria:

  • Apnea-hypopnea index < 10

Exclusion criteria:

  • Drug or alcohol abuse
  • Pregnancy
  • History or clinical signs of disease in the heart, lungs, brain, liver, kidneys or endocrine organs
  • Diabetes
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Please refer to this study by its identifier: NCT00438412

Department of Medical Research, Holstebro Hospital
Holstebro, Denmark, 7500
Sponsors and Collaborators
Regional Hospital Holstebro
Study Chair: Erling B Pedersen, Professor Regional Hospital Holstebro
  More Information

Responsible Party: Pia Holland Gjørup, Department of Medical Research Identifier: NCT00438412     History of Changes
Other Study ID Numbers: MED.RES.HOS.2006.01.PHH
Study First Received: February 20, 2007
Last Updated: April 17, 2008

Keywords provided by Regional Hospital Holstebro:
Angiotensin II
Arginine vasopressin
Atrial natriuretic peptide
Brain natriuretic peptide
Blood pressure

Additional relevant MeSH terms:
Sleep Apnea Syndromes
Sleep Apnea, Obstructive
Respiration Disorders
Respiratory Tract Diseases
Signs and Symptoms, Respiratory
Signs and Symptoms
Sleep Disorders, Intrinsic
Sleep Wake Disorders
Nervous System Diseases processed this record on May 23, 2017