LH/HCG Receptor Expression and Retrieval Rates

This study has suspended participant recruitment.
Sponsor:
Collaborator:
University of Athens
Information provided by (Responsible Party):
E.M. Kolibianakis, Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier:
NCT00438373
First received: February 21, 2007
Last updated: February 25, 2015
Last verified: February 2015
  Purpose

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up


Condition
Subfertility

Study Type: Observational
Study Design: Observational Model: Cohort
Time Perspective: Prospective
Official Title: Association of LH/HCG Receptor Expression and Retrieval Rates at Oocyte Pick up.

Further study details as provided by Aristotle University Of Thessaloniki:

Primary Outcome Measures:
  • LH/hCG receptor expression [ Time Frame: at oocyte retrieval ] [ Designated as safety issue: No ]

Estimated Enrollment: 100
Study Start Date: January 2007
Estimated Study Completion Date: January 2016
Estimated Primary Completion Date: January 2016 (Final data collection date for primary outcome measure)
Detailed Description:

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG or the day of oocyte retrieval and the retrieval rates at oocyte pick up.

For this purpose, m-RNA copy numbers will be assessed in the blood serum of patients undergoing ovarian stimulation for IVF on different days.

Furthermore, detailed ultrasound scans will be perfomed, as well as assesment of hormonal levels during ovarian stimulation.

  Eligibility

Ages Eligible for Study:   18 Years to 39 Years
Genders Eligible for Study:   Female
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population

infertile patients undergoing assisted reproduction tratment

Criteria

Inclusion criteria:

  • Age <39 years,
  • Body mass index (BMI) between 18 and 29 kg/m2,
  • Presence of both ovaries,
  • FSH levels <10 IU/l.

Exclusion criteria:

  • Endometriomas,
  • Polycystic ovarian syndrome.
  Contacts and Locations
Choosing to participate in a study is an important personal decision. Talk with your doctor and family members or friends about deciding to join a study. To learn more about this study, you or your doctor may contact the study research staff using the Contacts provided below. For general information, see Learn About Clinical Studies.

Please refer to this study by its ClinicalTrials.gov identifier: NCT00438373

Locations
Greece
Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital
Thessaloniki, Greece, 56429
Sponsors and Collaborators
Aristotle University Of Thessaloniki
University of Athens
Investigators
Study Director: Basil C Tarlatzis, MD, PhD Unit of Human Reproduction, 1st Department of Obs & Gyne, Aristotle University of Thessaloniki, Papageorgiou Hospital, Greece
  More Information

Publications:
Responsible Party: E.M. Kolibianakis, Professor, Aristotle University Of Thessaloniki
ClinicalTrials.gov Identifier: NCT00438373     History of Changes
Other Study ID Numbers: UHR-1
Study First Received: February 21, 2007
Last Updated: February 25, 2015
Health Authority: Greece: Ministry of Health and Welfare

Keywords provided by Aristotle University Of Thessaloniki:
Subfertility, Luteinizing hormone, receptor

ClinicalTrials.gov processed this record on September 03, 2015