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Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction

This study has been completed.
Sponsor:
ClinicalTrials.gov Identifier:
NCT00437931
First Posted: February 21, 2007
Last Update Posted: September 8, 2016
The safety and scientific validity of this study is the responsibility of the study sponsor and investigators. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Read our disclaimer for details.
Information provided by (Responsible Party):
avraham ishay, HaEmek Medical Center, Israel
  Purpose
Overt hyperthyroidism and hypothyroidism are associated with inverted hemodynamic changes.Regional blood flow disturbances (including intrathyroidal) were also reported in these thyroid disorders. The purpose of this study is to investigate the thyroid vascularity and blood flow by Color Flow Doppler Sonography in patients with subclinical thyroid dysfunction

Condition
Subclinical Hypothyroidism Hyperthyroidism Thyroid Dysfunction

Study Type: Observational
Study Design: Observational Model: Case Control
Time Perspective: Prospective

Resource links provided by NLM:


Further study details as provided by avraham ishay, HaEmek Medical Center, Israel:

Enrollment: 60
Study Start Date: February 2007
Study Completion Date: February 2008
Primary Completion Date: February 2008 (Final data collection date for primary outcome measure)
Groups/Cohorts
A
patients with subclinical hypothyroidism
B
patients with subclinical hyperthyroidism
C
patient with normal thyroid function.

Detailed Description:
Color Flow Doppler Sonography (CFDS) has become in the last years an increasing procedure to assess the thyroid blood flow. Previous studies showed specific changes of thyroid blood flow in hyperthyroidism, Hashimoto's thyroiditis and thyroid nodules when investigated by CFDS. Subclinical hyperthyroidism and hypothyroidism are common laboratory findings, defined by normal thyroid hormones concentrations along with ,respectively,decreased or increase Thyroid stimulating hormone (TSH) level. We purpose to investigate thyroid vascularity by CFDS in patients with subclinical hyperthyroidism or hypothyroidism and compared them with euthyroid patients.
  Eligibility

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with subclinical hypothyroidism and hyperthyroidism
Criteria

Inclusion Criteria:

  • patients with subclinical hypothyroidism or hyperthyroidism
  • patients with thyroid nodules and normal thyroid function

Exclusion Criteria:

  • patients who are taking thyroxine, antithyroid drugs, lithium or amiodarone
  • patients who had thyroid surgery or radioiodine therapy
  • patients with NYHA class 3 or 4 heart failure
  Contacts and Locations
Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00437931


Locations
Israel
Haemek Medical Center, Department of Radiology
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Investigators
Principal Investigator: Avraham Ishay, MD Haemek Medical Center, Endocrine Institute, Afula, Israel
Study Chair: Leonid Chervinsky Haemek Medical Center, Department of Radiology, Afula , Israel
Study Chair: Rafael Luboshitzky, MD Haemek Medical Center, Endocrine Institute, Afula, Israel
  More Information

Responsible Party: avraham ishay, Dr, HaEmek Medical Center, Israel
ClinicalTrials.gov Identifier: NCT00437931     History of Changes
Other Study ID Numbers: 006-07-EMC
First Submitted: February 19, 2007
First Posted: February 21, 2007
Last Update Posted: September 8, 2016
Last Verified: September 2016

Keywords provided by avraham ishay, HaEmek Medical Center, Israel:
hypothyroidism
hyperthyroidism
thyroid dysfunction
ultrasound
doppler

Additional relevant MeSH terms:
Thyroid Diseases
Hypothyroidism
Hyperthyroidism
Endocrine System Diseases