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Color Flow Doppler Ultrasound in Subclinical Thyroid Dysfunction

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ClinicalTrials.gov Identifier: NCT00437931
Recruitment Status : Completed
First Posted : February 21, 2007
Last Update Posted : September 8, 2016
Information provided by (Responsible Party):
avraham ishay, HaEmek Medical Center, Israel

Brief Summary:
Overt hyperthyroidism and hypothyroidism are associated with inverted hemodynamic changes.Regional blood flow disturbances (including intrathyroidal) were also reported in these thyroid disorders. The purpose of this study is to investigate the thyroid vascularity and blood flow by Color Flow Doppler Sonography in patients with subclinical thyroid dysfunction

Condition or disease
Subclinical Hypothyroidism Hyperthyroidism Thyroid Dysfunction

Detailed Description:
Color Flow Doppler Sonography (CFDS) has become in the last years an increasing procedure to assess the thyroid blood flow. Previous studies showed specific changes of thyroid blood flow in hyperthyroidism, Hashimoto's thyroiditis and thyroid nodules when investigated by CFDS. Subclinical hyperthyroidism and hypothyroidism are common laboratory findings, defined by normal thyroid hormones concentrations along with ,respectively,decreased or increase Thyroid stimulating hormone (TSH) level. We purpose to investigate thyroid vascularity by CFDS in patients with subclinical hyperthyroidism or hypothyroidism and compared them with euthyroid patients.

Study Type : Observational
Actual Enrollment : 60 participants
Observational Model: Case Control
Time Perspective: Prospective
Study Start Date : February 2007
Primary Completion Date : February 2008
Study Completion Date : February 2008

Resource links provided by the National Library of Medicine

U.S. FDA Resources

patients with subclinical hypothyroidism
patients with subclinical hyperthyroidism
patient with normal thyroid function.

Information from the National Library of Medicine

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Ages Eligible for Study:   18 Years to 75 Years   (Adult, Senior)
Sexes Eligible for Study:   All
Accepts Healthy Volunteers:   No
Sampling Method:   Probability Sample
Study Population
patients with subclinical hypothyroidism and hyperthyroidism

Inclusion Criteria:

  • patients with subclinical hypothyroidism or hyperthyroidism
  • patients with thyroid nodules and normal thyroid function

Exclusion Criteria:

  • patients who are taking thyroxine, antithyroid drugs, lithium or amiodarone
  • patients who had thyroid surgery or radioiodine therapy
  • patients with NYHA class 3 or 4 heart failure

Information from the National Library of Medicine

To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.

Please refer to this study by its ClinicalTrials.gov identifier (NCT number): NCT00437931

Haemek Medical Center, Department of Radiology
Afula, Israel, 18101
Sponsors and Collaborators
HaEmek Medical Center, Israel
Principal Investigator: Avraham Ishay, MD Haemek Medical Center, Endocrine Institute, Afula, Israel
Study Chair: Leonid Chervinsky Haemek Medical Center, Department of Radiology, Afula , Israel
Study Chair: Rafael Luboshitzky, MD Haemek Medical Center, Endocrine Institute, Afula, Israel

Responsible Party: avraham ishay, Dr, HaEmek Medical Center, Israel
ClinicalTrials.gov Identifier: NCT00437931     History of Changes
Other Study ID Numbers: 006-07-EMC
First Posted: February 21, 2007    Key Record Dates
Last Update Posted: September 8, 2016
Last Verified: September 2016

Keywords provided by avraham ishay, HaEmek Medical Center, Israel:
thyroid dysfunction

Additional relevant MeSH terms:
Thyroid Diseases
Endocrine System Diseases